RESEARCH PROTOCOL

Estimation of the risk of NVAMD and other vision disorders from exposure to semaglutide

Version: 1

1 List of Abbreviations

NVAMD	neovascular age-related macular degeneration
NIU	non-infectious uveitis
GLP-1 RA	glucagon-like peptide 1 receptor agonist
VEGF	vascular endothelial growth factor
SGLT2	sodium-glucose cotransporter-2
DPP4	dipeptidyl peptidase-4
OHDSI	Observational Health Data Sciences and Informatics
HADES	Health Analytics Data-to-Evidence Suite
T2DM	Type 2 diabetes mellitus
CCI	Charlson Comorbidity Index
DCSI	Diabetes Complications Severity Index
SMD	standardized mean difference
EASE	expected absolute systematic error
MDRR	minimum detectable relative risk
ARVO	The Association for Research in Vision and Ophthalmology

2 Responsible Parties

2.1 Investigators

Investigator	Institution/Affiliation
Cindy Cai, MD, MS *	Wilmer Eye Institute, Johns Hopkins Hospital, ccai6@jhmi.edu
Brian Toy, MD	USC, Brian.Toy@med.usc.edu
	Eye Care and Vision Research Workgroup
* Principal Investigator

2.2 Disclosures

This study is undertaken within Observational Health Data Sciences and Informatics (OHDSI), an open collaboration.

3 Abstract

Background: Despite its cardiovascular and kidney benefits, semaglutide has been recently linked to ophthalmic complications including neovascular age-related macular degeneration (NVAMD). It may also have anti-inflammatory properties and a recent report suggests it may have a protective association against the incidence of non-infectious uveitis.

Purpose: To estimate the risk of NVAMD and with semaglutide use compared with other GLP-1 RAs (dulaglutide, and exenatide), and non-GLP-1 RA medications (including empagliflozin, sitagliptin, and glipizide) among adults with type 2 diabetes mellitus. To estimate the relative incidence rate of NVAMD associated with GLP-1 RAs and non-GLP-1 RAs exposure compared with non-exposure. Parallel analyses will be performed with non-infectious uveitis as an outcome.

Design: Retrospective study employing 1) an active comparator, new-user cohort design, 2) self-controlled case series across the OHDSI Evidence Network.

Subjects: Adults (≥ 18 years) with type 2 diabetes mellitus who are users of semaglutide (a GLP-1 RA), dulaglutide (a GLP-1 RA), exenatide (a GLP-1 RA), empagliflozin (an SGLT2 inhibitor), sitagliptin (a DPP4 inhibitor), or glipizide (a sulfonylurea)

Methods: 1) New-User active Comparator Cohort Design: Patients who are new-users of semaglutide will be compared to propensity score matched patients with each of the other GLP-1 RA and non-GLP-1 RA medications. We will deploy the large-scale propensity score method that adjusts for a comprehensive range of baseline characteristics. Cox models will be used to compare the time to NVAMD between patients who receive semaglutide with patients who receive empagliflozin, sitagliptin, and glipizide. Similar comparisons will be made between the other GLP-1 RA (dulaglutide and exenatide) with each of the comparators. 2) Self-Controlled Case Series: the incidence rate of NVAMD during periods of exposure with each of the T2DM medications will be compared to the incidence rate of NVAMD during control periods of non-exposure using Poisson regression models. Parallel analyses will be performed with non-infectious uveitis as an outcome.

Conclusions: Clarifying the risk of NVAMD associated with semaglutide (and other GLP-1 RA) by 1) characterizing the incidence in the exposed population, and 2) estimating the risk of exposure will help guide the appropriate use of this medication. Parallel analyses will be performed with non-infectious uveitis as an outcome.

4 Amendments and Updates

5 Milestones

6 Rationale and Background

Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is approved by the US Food and Drug Administration (FDA) for the treatment of type 2 diabetes mellitus. It has been shown to reduce the rate of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke in patients with type 2 diabetes at high cardiovascular risk.[1] Furthermore, results from the recent FLOW trial suggest that semaglutide can reduce clinically important kidney outcomes and death from cardiovascular causes in patients with type 2 diabetes mellitus and chronic kidney disease.[1,2] Given their benefit, the American Diabetes Association’s Standards of Medical Care in Diabetes recommends GLP-1 RA in patients with type 2 diabetes mellitus with atherosclerotic cardiovascular disease and chronic kidney disease.[3]

Despite the benefits of semaglutide, it has been linked to several adverse ophthalmic consequences previously studied by the OHDSI group.[4] Most recently, a retrospective study published in JAMA Ophthalmology linked the exposure of GLP-1 RAs to a two-fold increased risk of neovascular age related macular degeneration (NVAMD) among patients 66 and older.[5] The mechanism of this association is unclear, possible theories include the exacerbation of underlying hypoxic mechanisms or increased level of CXCL12, a chemokine that typically rises under hypoxic conditions and promotes angiogenesis and specifically boosts VEGF expression.[5]

Conversely, recent studies suggest GLP-1 RA may have anti-inflammatory properties, perhaps through reduced production of pro-inflammatory cytokines, such as IL-6, IL-1beta, TNF-alpha, and CRP, and increased production of anti-inflammatory cytokines, such as IL-10.[6] There have been recent protective associations between GLP-1 RA use and inflammatory bowel disease,[7] and as the GLP-1 receptor is expressed in the eye, there may be a direct protective effect.

Given the common usage of GLP-1 RAs, specifically semaglutide, there exists a need to clarify whether there is an association with NVAMD or uveitis in a larger retrospective cohort study.

7 Study Objectives

The purpose of this study is to investigate NVAMD from use of semaglutide for the treatment of type 2 diabetes mellitus.

1. Among patients with type 2 diabetes mellitus, is the risk for NVAMD higher among patients who use semaglutide as compared with a non-GLP-1 RA anti-diabetic medication?
2. Among patients with type 2 diabetes mellitus, is the risk for NVAMD higher among patients who use semaglutide as compared with other GLP-1 RA anti-diabetic medications?

The study also will investigate the incidence of non-infectious uveitis (NIU) from use of semaglutide for the treatment of type 2 diabetes mellitus.

1. Among patients with type 2 diabetes mellitus, is the risk for NIU lower among patients who use semaglutide as compared with a non-GLP-1 RA anti-diabetic medication?
2. Among patients with type 2 diabetes mellitus, is the risk for NIU lower among patients who use semaglutide as compared with other GLP-1 RA anti-diabetic medications?

8 Research Methods

8.1 Study Design/Data Source(s)

This will be a retrospective cohort study employing 2 study designs: 1) an active comparator, new-user cohort design, comparing the risk of NVAMD or NIU in adults with types 2 diabetes mellitus exposed to semaglutide compared with other GLP-1 RA medications and non-GLP-1 RA anti-diabetic medications, and 2) a self-controlled case-series. Other GLP-1 RA medications will include dulaglutide and exenatide. Non-GLP-1 RA comparators will include other second-line treatments for diabetes including empagliflozin (a SGLT2 inhibitor), sitagliptin (a DPP4 inhibitor), and glipizide (a sulfonylurea). These comparators were chosen based on the most commonly occurring medication within those classes from the LEGEND-T2DM study. (https://ohdsi-studies.github.io/LegendT2dm/Protocol)

8.2 Study Population

We will include all adults (≥ 18 years) with type 2 diabetes mellitus in each data source who meet the cohort entry criteria for each exposure cohort (detailed below).

8.3 Exposures

The exposure is receipt of semaglutide (GLP-1 RA), dulaglutide (GLP-1 RA), exenatide (GLP-1 RA), empagliflozin (a SGLT2 inhibitor), sitagliptin (a DPP4 inhibitor), or glipizide (a sulfonylurea) based on the definitions of LEGEND-T2DM. (https://ohdsi-studies.github.io/LegendT2dm/Protocol) For the new-user active comparator cohort design, these will include patients with T2DM withC prior metformin monotherapy who initiate treatment with one of the four medications. Patients must have one year of observation prior to the index date, no prior drug exposure to a comparator second-line or anti-diabetic agents, and at most 30 days of insulin exposure before the drug exposure date.

As a sensitivity analysis, we will examine patients with each of these anti-diabetic medication exposures but without the second-line therapy requirement, meaning that they can be on another anti-diabetic medication at the time of cohort entry, not required to be on prior metformin, but still at most have 30 days of insulin exposure.

8.4 Outcomes

1. Specific NVAMD
2. Sensitive NVAMD
3. Non-infectious Ocular Inflammation
4. Anterior Uveitis
5. Chorioretinal Inflammation
6. Panuveitis
7. Retinal Vasculitis
8. Non-infectious Ocular Inflammation (excluding intraocular surgery)
9. Anterior Uveitis (excluding intraocular surgery)
10. Chorioretinal Inflammation (excluding intraocular surgery)
11. Panuveitis (excluding intraocular surgery)
12. Retinal Vasculitis (excluding intraocular surgery)

See human-readable description of the outcomes in the Cohort Definitions section below.

8.5 Covariates

We will deploy the large-scale propensity score method that adjusts for a comprehensive range of baseline characteristic.[8]

8.6 Negative Controls

Negative controls will be picked to represent exposure-outcome pairs where no causal effect is expected to exist. We will use the set of negative controls that was used in our prior study of semaglutide and ophthalmic complications.[9]

9 Data Analysis Plan

9.1 General

Various standardized analytics available in the OHDSI community will be applied. The Strategus pipeline will be used to call various packages in the HADES library for A) data characterization (A1‑cohort diagnostics, A2‑cohort features, A3‑incidence rates, A4-time-to-event), B) population-level effect estimation (C1–comparative cohort study, C2‑‑self-controlled case-series)[10,11] The R package versioning history will be recorded using the renv file and stored in the study Github repository.

9.2 Data Characterization

9.2.1 Cohort Diagnostics

The R package CohortDiagnostics will be executed for all target, comparator, indication, and outcome cohorts to evaluate measurement error in the phenotype development and evaluation process.

9.2.2 Cohort Features

The Characterization and FeatureExtraction packages in HADES will be used to identify features of patients in each exposure group who had the outcome and those who did not have the outcome. Features will be extracted from the 365 day observation prior to cohort entry and will include variables such as demographic data (sex, age group, race, ethnicity), prior conditions/drug exposures/procedures/measurements/devices/observations, and risk scores (e.g., Charlson comorbidity index, DCSI, CHADS2VASC score).

9.2.3 Incidence Rates

The Characterization package in HADES will be used to calculate the incidence rates of the outcome for each exposure cohort and indication cohort. The rate is calculated as the number of outcomes during the time-at-risk divided by the number of total person days.

9.2.3.1 Calculation of time-at-risk

The primary method of calculating time-at-risk will be while the patient is “on-treatment”. This is defined as from the start of cohort entry (or diabetes drug initiation) until the end of the continuous drug exposure, defined as a gap in exposure of >30 days, end of continuous observation period, or study period.

9.2.4 Time-to-Event

Time to the outcomes of NVAMD will be calculated for each exposure cohort.[12]

9.3 Population-Level Effect Estimation

9.3.1 Comparative Cohort Study

The CohortMethod and Cyclops packages in Hades will be used. Large-scale propensity score methods will be used to match the target exposure cohort with the comparator export cohort (e.g., semaglutide vs empagliflozin) using 1:1 propensity score matching.[8] Given the concern for increasing usage of semaglutide in recent years, we will also perform a sensitivity analysis with calendar year restriction: Dec2017-Jan2020, Feb2020-June2021, July2021-Dec2024. These dates were chosen based on the date of FDA approval for semaglutide for T2DM, the COVID pandemic, and eventual uptick in semaglutide prescriptions. Cox proportional hazards models will be used to estimate the risk of NVAMD while on treatment using the intent-to-treat design. Negative controls will be used to assess residual bias.

Similar analysis will be performed using NIU as the outcome.

9.3.2 Self-Controlled Case Series

The SelfControlledCaseSeries and Cyclops packages in Hades will be used to estimate the relative incidence of NVAMD using a self-controlled case-series design. Patients with T2DM and NVAMD diagnosed after the first year in the observation period will be included in the analysis. We will use Poisson regression models to compare the incidence rates of NVAMD while on-treatment with a T2DM medication relative to control time during the observation period. Control time will include periods during the study period when the patient had diagnosed T2DM and excludes the first 365 days of the observation period. Models will have separate adjustments for the pre-exposure time window and potential effects of seasonality and calendar time. Diagnostics will be run to evaluate whether this was an appropriate analysis.

Similar analysis will be performed using NIU as the outcome.

10 Study Diagnostics

Residual bias can still remain in observational studies even after PS adjustment is applied to control for measured confounding.[13,14] To address this, we conduct negative control (falsification) outcome experiments for each comparison and outcome, assuming the null hypothesis of no differential effect (i.e., risk ratio (RR) = 1) is true for each negative control outcome. We identified 96 negative controls using a data-driven algorithm that selects OMOP condition concept occurrences with similar prevalence to the outcomes of interest but lacking evidence of association with exposures in published literature, drug product labels, and spontaneous reports.[15] These were then verified through expert review. The list of negative controls is provided below. From these experiments, we derive an empirical null distribution to account for residual study bias. Using this empirical null, we calibrate each RR estimate, its 95% confidence interval (CI), and the p-value to test for the null hypothesis. We consider an RR significantly different from the null if the calibrated p-value is below 0.05, without adjusting for multiple testing.

To ensure the reliability and generalizability of all comparisons, we evaluate study diagnostics while blinded to the results, and only present estimates that successfully pass these diagnostics.[16,17] For the primary analysis using the active comparator new-user cohort design, our diagnostics include: (1) preference score distributions between the target and comparator cohorts to evaluate empirical equipoise and population generalizability; (2) cohort balance before and after PS adjustment, defined by the absolute standardized mean differences (SMDs) on extensive patient characteristics for each target-comparator-analysis; (3) negative control calibration plots to assess residual bias, quantified by the Expected Absolute Systematic Error (EASE) derived from the empirical null distribution; and for the primary analysis (Cox PH model), (4) Kaplan-Meier plots to visually examine hazard ratio proportionality assumptions. A study passes diagnostics and contributes to the meta analysis if more than 10% of patients have preference scores between 0.3 and 0.7 on both arms, maximum SMD < 0.1 after PS adjustment, and EASE < 0.25. For the self-controlled case-series analysis, study diagnostics include (1) time trend check that tests for stable background hazards over time periods after PS adjustment, and (2) pre-exposure check to ensure comparative effects in 30 days pre-exposure do not significantly differ from the null to rule out reverse causality; a study passes diagnostics if the p-values for both checks are > 0.05. For both analyses we further evaluate the meta-analytic minimally detectable risk ratio (MDRR) as a proxy of statistical power and only admit a meta-analytic RR estimate if meta-analytic MDRR < 10.[18]

10.1 Diagnostic Thresholds for Cohort Method

Study Diagnostics	Threshold
Covariate balance (Standardized Mean Difference)	<0.1
Empirical Equipoise (Preference Score)	>0.1
Residual Bias (Expected Absolute Systematic Error (EASE))	<0.25
Meta-analysis Heterogeneity	<0.4
Meta-analysis Minimum Detectable Relative Risk (MDRR)	<10

10.2 Diagnostic Thresholds for Self-Controlled Case-Series

Study Diagnostics	Threshold
Pre-exposure	>0.05
Time Trend	>0.05
Residual Bias (Expected Absolute Systematic Error (EASE))	<0.25
Meta-analysis Minimum Detectable Relative Risk (MDRR)	<10

11 Strengths and Limitations

When executed, this will be the largest study examining the association between semaglutide and the risk of NVAMD and NIU. Other strengths of this study include the diversity of the sample (from multiple institutions, multiple countries), and rigorous study design.

Limitations are mainly due to the retrospective nature of the study, which might have residual confounding despite propensity score matching and stratified analyses.

12 Protection of Human Subjects

Each participating institution will seek IRB approval for this study as dictated by local governance.

13 Plans for Disseminating and Communicating Study Results

The results will be shared and discussed among the study participants and broader OHDSI community during the weekly Tuesday community calls. This work will be presented at conferences (OHDSI Global Symposium and/or ARVO) and published as a manuscript.

References

1

Marso SP, Bain SC, Consoli A, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. New England Journal of Medicine 2016;375:1834–44. doi:10.1056/NEJMoa1607141

2

Perkovic V, Tuttle KR, Rossing P, et al. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes. New England Journal of Medicine 2024;391:109–21. doi:10.1056/NEJMoa2403347

3

American Diabetes Association Professional Practice Committee. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2022. Diabetes Care 2021;45:S125–43. doi:10.2337/dc22-S009

4

Cai CX, Hribar M, Baxter S, et al. Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy. JAMA Ophthalmology 2025;143:304–14. doi:10.1001/jamaophthalmol.2024.5989

5

Shor R, Mihalache A, Noori A, et al. Glucagon-like peptide-1 receptor agonists and risk of neovascular age-related macular degeneration. JAMA Ophthalmology 2025.

6

Mehdi SF, Pusapati S, Anwar MS, et al. Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent. Frontiers in Immunology 2023;14:1148209.

7

Bendotti G, Montefusco L, Lunati ME, et al. The anti-inflammatory and immunological properties of GLP-1 receptor agonists. Pharmacological Research 2022;182:106320.

8

Tian Y, Schuemie MJ, Suchard MA. Evaluating large-scale propensity score performance through real-world and synthetic data experiments. International Journal of Epidemiology 2018;47:2005–14.

9

Protocol.knit. 2025.https://ohdsi-studies.github.io/SemaglutideNaion/protocol.html (accessed 12 Jun 2025).

10

OHDSI/Strategus. 2024.https://github.com/OHDSI/Strategus (accessed 29 Apr 2023).

11

Schuemie M, Reps J, Black A, et al. Health-Analytics Data to Evidence Suite (HADES): Open-Source Software for Observational Research. IOS Press 2024. 966–70. doi:10.3233/SHTI231108

12

Reps JM, Schuemie MJ, Suchard MA, et al. Design and implementation of a standardized framework to generate and evaluate patient-level prediction models using observational healthcare data. Journal of the American Medical Informatics Association: JAMIA 2018;25:969–75. doi:10.1093/jamia/ocy032

13

Schuemie MJ, Hripcsak G, Ryan PB, et al. Empirical confidence interval calibration for population-level effect estimation studies in observational healthcare data. Proceedings of the National Academy of Sciences of the United States of America 2018;115:2571–7. doi:10.1073/pnas.1708282114

14

Schuemie MJ, Hripcsak G, Ryan PB, et al. Robust empirical calibration of p‐values using observational data. Statistics in Medicine 2016;35:3883–8. doi:10.1002/sim.6977

15

Voss EA, Boyce RD, Ryan PB, et al. Accuracy of an automated knowledge base for identifying drug adverse reactions. Journal of Biomedical Informatics 2017;66:72–81. doi:10.1016/j.jbi.2016.12.005

16

Schuemie MJ, Cepeda MS, Suchard MA, et al. How Confident Are We about Observational Findings in Healthcare: A Benchmark Study. Harvard Data Science Review 2020;2. doi:10.1162/99608f92.147cc28e

17

Schuemie MJ, Ryan PB, Hripcsak G, et al. Improving reproducibility by using high-throughput observational studies with empirical calibration. Philosophical Transactions Series A, Mathematical, Physical, and Engineering Sciences 2018;376:20170356. doi:10.1098/rsta.2017.0356

18

Protocol.knit. 2025.https://ohdsi-studies.github.io/SemaglutideNaion/protocol.html#References (accessed 12 Jun 2025).

Appendix

A Indication Cohort

A.1 Persons with Type 2 DM and no prior T1DM or secondary Diabetes

A.1.1 Cohort Entry Events

People may enter the cohort when observing any of the following:

1. condition occurrences of ‘Type 2 diabetes mellitus’.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
2. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

A.1.2 Cohort Exit

The person also exists the cohort at the end of continuous observation.

A.1.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

A.1.4 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

A.1.5 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

A.1.6 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B Exposure Cohorts for Cohort Design

B.1 New user of semaglutide as 2nd line prior T2DM and metformin

B.1.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘semaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.1.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists excluding semaglutide’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.1.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘semaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.1.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.1.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.1.6 Concept: semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
793143	semaglutide	1991302	RxNorm	NO	YES	NO

B.1.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.1.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.1.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.1.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.1.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.1.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.1.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.1.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.1.15 Concept: GLP-1 receptor agonists excluding semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	YES	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.2 New user of dulaglutide as 2nd line prior T2DM and metformin

B.2.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘dulaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.2.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists excluding dulaglutide’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.2.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘dulaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.2.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.2.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.2.6 Concept: dulaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO

B.2.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.2.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.2.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.2.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.2.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.2.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.2.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.2.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.2.15 Concept: GLP-1 receptor agonists excluding dulaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	YES	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.3 New user of exenatide as 2nd line prior T2DM and metformin

B.3.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘exenatide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.3.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists excluding exenatide’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.3.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘exenatide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.3.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.3.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.3.6 Concept: exenatide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1583722	exenatide	60548	RxNorm	NO	YES	NO

B.3.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.3.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.3.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.3.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.3.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.3.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.3.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.3.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.3.15 Concept: GLP-1 receptor agonists excluding exenatide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	YES	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.4 New user of empagliflozin as 2nd line prior T2DM and metformin

B.4.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘empagliflozin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.4.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors except empagliflozin’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.4.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘empagliflozin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.4.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.4.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.4.6 Concept: empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO

B.4.7 Concept: SGLT2 inhibitors except empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	YES	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.4.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.4.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.4.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.4.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.4.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.4.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.4.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.4.15 Concept: GLP-1 receptor agonists

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.5 New user of sitagliptin as 2nd line prior T2DM and metformin

B.5.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘sitagliptin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.5.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors except sitagliptin’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.5.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘sitagliptin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.5.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.5.5 Concept: DPP4 inhibitors except sitagliptin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	YES	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.5.6 Concept: sitagliptin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1580747	sitagliptin	593411	RxNorm	NO	YES	NO

B.5.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.5.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.5.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.5.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.5.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.5.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.5.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.5.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.5.15 Concept: GLP-1 receptor agonists

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.6 New user of glipizide as 2nd line prior T2DM and metformin

B.6.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘glipizide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.6.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas except glipizide’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.6.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘glipizide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.6.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.6.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.6.6 Concept: glipizide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1560171	glipizide	4821	RxNorm	NO	YES	NO

B.6.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.6.8 Concept: Sulfonylureas except glipizide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	YES	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.6.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.6.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.6.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.6.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.6.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.6.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.6.15 Concept: GLP-1 receptor agonists

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.7 New user of semaglutide with prior T2DM

B.7.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘semaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.7.2 Additional Inclusion Criteria

I. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.7.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘semaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.7.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.7.5 Concept: semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
793143	semaglutide	1991302	RxNorm	NO	YES	NO

B.7.6 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.7.7 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.7.8 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.7.9 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.7.10 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B.8 New user of dulaglutide with prior T2DM

B.8.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘dulaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.8.2 Additional Inclusion Criteria

I. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.8.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘dulaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.8.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.8.5 Concept: dulaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO

B.8.6 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.8.7 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.8.8 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.8.9 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.8.10 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B.9 New user of exenatide with prior T2DM

B.9.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘exenatide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.9.2 Additional Inclusion Criteria

I. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.9.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘exenatide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.9.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.9.5 Concept: exenatide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1583722	exenatide	60548	RxNorm	NO	YES	NO

B.9.6 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.9.7 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.9.8 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.9.9 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.9.10 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B.10 New user of empagliflozin with prior T2DM

B.10.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘empagliflozin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.10.2 Additional Inclusion Criteria

I. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.10.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘empagliflozin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.10.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.10.5 Concept: empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO

B.10.6 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.10.7 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.10.8 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.10.9 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.10.10 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B.11 New user of sitagliptin with prior T2DM

B.11.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘sitagliptin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.11.2 Additional Inclusion Criteria

I. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.11.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘sitagliptin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.11.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.11.5 Concept: sitagliptin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1580747	sitagliptin	593411	RxNorm	NO	YES	NO

B.11.6 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.11.7 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.11.8 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.11.9 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.11.10 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B.12 New user of glipizide with prior T2DM

B.12.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘glipizide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.12.2 Additional Inclusion Criteria

I. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

B.12.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘glipizide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.12.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.12.5 Concept: glipizide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1560171	glipizide	4821	RxNorm	NO	YES	NO

B.12.6 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.12.7 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.12.8 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.12.9 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.12.10 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

---

B.13 New user of semaglutide as 2nd line prior T2DM and metformin Dec2017-Jan2020

B.13.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘semaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.13.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists excluding semaglutide’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

VIII. index date between 1Dec2017 and 31Jan2020

Entry events with the following event criteria: starting between December 1, 2017 and January 31, 2020.

B.13.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘semaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.13.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.13.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.13.6 Concept: semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
793143	semaglutide	1991302	RxNorm	NO	YES	NO

B.13.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.13.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.13.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.13.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.13.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.13.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.13.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.13.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.13.15 Concept: GLP-1 receptor agonists excluding semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	YES	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.14 New user of semaglutide as 2nd line prior T2DM and metformin Feb2020-June2021

B.14.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘semaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.14.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists excluding semaglutide’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

VIII. index date between 1Feb2020 and 30Jun2021

Entry events with the following event criteria: starting between February 1, 2020 and June 30, 2021.

B.14.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘semaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.14.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.14.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.14.6 Concept: semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
793143	semaglutide	1991302	RxNorm	NO	YES	NO

B.14.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.14.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.14.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.14.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.14.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.14.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.14.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.14.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.14.15 Concept: GLP-1 receptor agonists excluding semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	YES	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.15 New user of semaglutide as 2nd line prior T2DM and metformin July2021-Dec2024

B.15.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘semaglutide’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.15.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists excluding semaglutide’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

VIII. index date between 1Jul2021 and 31Dec2023

Entry events with the following event criteria: starting between July 1, 2021 and December 31, 2024.

B.15.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘semaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.15.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.15.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.15.6 Concept: semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
793143	semaglutide	1991302	RxNorm	NO	YES	NO

B.15.7 Concept: SGLT2 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.15.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.15.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.15.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.15.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.15.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.15.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.15.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.15.15 Concept: GLP-1 receptor agonists excluding semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	YES	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.16 New user of empagliflozin as 2nd line prior T2DM and metformin Dec2017-Jan2020

B.16.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘empagliflozin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.16.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors except empagliflozin’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

VIII. index date between 1Dec2017 and 31Jan2020

Entry events with the following event criteria: starting between December 1, 2017 and January 31, 2020.

B.16.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘empagliflozin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.16.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.16.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.16.6 Concept: empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO

B.16.7 Concept: SGLT2 inhibitors except empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	YES	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.16.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.16.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.16.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.16.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.16.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.16.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.16.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.16.15 Concept: GLP-1 receptor agonists

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.17 New user of empagliflozin as 2nd line prior T2DM and metformin Feb2020-June2021

B.17.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘empagliflozin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.17.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors except empagliflozin’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

VIII. index date between 1Feb2020 and 30Jun2021

Entry events with the following event criteria: starting between February 1, 2020 and June 30, 2021.

B.17.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘empagliflozin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.17.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.17.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.17.6 Concept: empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO

B.17.7 Concept: SGLT2 inhibitors except empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	YES	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.17.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.17.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.17.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.17.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.17.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.17.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.17.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.17.15 Concept: GLP-1 receptor agonists

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

B.18 New user of empagliflozin as 2nd line prior T2DM and metformin July2021-Dec2024

B.18.1 Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

1. drug exposure of ‘empagliflozin’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Restrict entry events to with all of the following criteria:

1. with the following event criteria: who are >= 18 years old.
2. having at least 1 condition occurrence of ‘Type 2 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
3. having no condition occurrences of ‘Type 1 diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.
4. having no condition occurrences of ‘Secondary diabetes mellitus’, starting anytime on or before cohort entry start date; allow events outside observation period.

B.18.2 Additional Inclusion Criteria

I. Prior metformin use

Entry events with any of the following criteria:

1. having at least 1 drug era of ‘Metformin’, starting anytime up to 90 days before cohort entry start date; allow events outside observation period; with era length >= 90 days.
2. having at least 3 drug exposures of ‘Metformin’, starting anytime on or before cohort entry start date; allow events outside observation period.

II. No prior GLP-1 RA exposure

Entry events having no drug exposures of ‘GLP-1 receptor agonists’, starting anytime on or before cohort entry start date; allow events outside observation period.

III. No prior DPP4 inhibitor exposure

Entry events having no drug exposures of ‘DPP4 inhibitors’, starting anytime on or before cohort entry start date; allow events outside observation period.

IV. No prior SGLT-2 inhibitor exposure

Entry events having no drug exposures of ‘SGLT2 inhibitors except empagliflozin’, starting anytime on or before cohort entry start date; allow events outside observation period.

V. No prior SU exposure

Entry events having no drug exposures of ‘Sulfonylureas’, starting anytime on or before cohort entry start date; allow events outside observation period.

VI. No prior other anti-diabetic exposure

Entry events having no drug exposures of ‘Other anti-diabetics’, starting anytime on or before cohort entry start date; allow events outside observation period.

VII. No prior insulin use or combo initiation: Proxy for < 30 days drug era anytime before index and no combination use on index

Entry events with all of the following criteria:

1. having no drug eras of ‘Insulin’, starting anytime up to 30 days before cohort entry start date; allow events outside observation period; with era length > 30 days.
2. having no drug eras of ‘Insulin’, starting between 30 days before and 0 days after cohort entry start date; allow events outside observation period.

VIII. index date between 1Jul2021 and 31Dec2023

Entry events with the following event criteria: starting between July 1, 2021 and December 31, 2024.

B.18.3 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘empagliflozin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

B.18.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

B.18.5 Concept: DPP4 inhibitors

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43013884	alogliptin	1368001	RxNorm	NO	YES	NO
40239216	linagliptin	1100699	RxNorm	NO	YES	NO
40166035	saxagliptin	857974	RxNorm	NO	YES	NO
1580747	sitagliptin	593411	RxNorm	NO	YES	NO
19122137	vildagliptin	596554	RxNorm	NO	YES	NO

B.18.6 Concept: empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO

B.18.7 Concept: SGLT2 inhibitors except empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
43526465	canagliflozin	1373458	RxNorm	NO	YES	NO
44785829	dapagliflozin	1488564	RxNorm	NO	YES	NO
45774751	empagliflozin	1545653	RxNorm	YES	YES	NO
793293	ertugliflozin	1992672	RxNorm	NO	YES	NO

B.18.8 Concept: Sulfonylureas

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1594973	chlorpropamide	2404	RxNorm	NO	YES	NO
1597756	glimepiride	25789	RxNorm	NO	YES	NO
1560171	glipizide	4821	RxNorm	NO	YES	NO
19097821	gliquidone	25793	RxNorm	NO	YES	NO
1559684	glyburide	4815	RxNorm	NO	YES	NO
1502809	tolazamide	10633	RxNorm	NO	YES	NO
1502855	tolbutamide	10635	RxNorm	NO	YES	NO

B.18.9 Concept: Other anti-diabetics

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1529331	acarbose	16681	RxNorm	NO	YES	NO
1530014	acetohexamide	173	RxNorm	NO	YES	NO
730548	bromocriptine	1760	RxNorm	NO	YES	NO
19033498	carbutamide	2068	RxNorm	NO	YES	NO
19001409	glibornuride	102846	RxNorm	NO	YES	NO
19059796	gliclazide	4816	RxNorm	NO	YES	NO
19001441	glymidine	102848	RxNorm	NO	YES	NO
1510202	miglitol	30009	RxNorm	NO	YES	NO
1502826	nateglinide	274332	RxNorm	NO	YES	NO
1525215	pioglitazone	33738	RxNorm	NO	YES	NO
1516766	repaglinide	73044	RxNorm	NO	YES	NO
1547504	rosiglitazone	84108	RxNorm	NO	YES	NO
1515249	troglitazone	72610	RxNorm	NO	YES	NO

B.18.10 Concept: Insulin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1596977	insulin, regular, human	253182	RxNorm	NO	YES	NO
1550023	insulin lispro	86009	RxNorm	NO	YES	NO
1567198	insulin aspart, human	51428	RxNorm	NO	YES	NO
1502905	insulin glargine	274783	RxNorm	NO	YES	NO
1513876	insulin lispro protamine, human	314684	RxNorm	NO	YES	NO
1531601	insulin aspart protamine, human	352385	RxNorm	NO	YES	NO
1586346	insulin, regular, pork	221109	RxNorm	NO	YES	NO
1544838	insulin glulisine, human	400008	RxNorm	NO	YES	NO
1516976	insulin detemir	139825	RxNorm	NO	YES	NO
1590165	insulin, regular, beef-pork	235275	RxNorm	NO	YES	NO
1513849	lente insulin, human	314683	RxNorm	NO	YES	NO
1562586	lente insulin, pork	93108	RxNorm	NO	YES	NO
1588986	insulin human, rDNA origin	631657	RxNorm	NO	YES	NO
1513843	lente insulin, beef-pork	314682	RxNorm	NO	YES	NO
1586369	ultralente insulin, human	221110	RxNorm	NO	YES	NO
35605670	insulin argine	1740938	RxNorm	NO	YES	NO
35602717	insulin degludec	1670007	RxNorm	NO	YES	NO
21600713	INSULINS AND ANALOGUES	A10A	ATC	NO	YES	NO
19078608	insulin, protamine zinc, beef-pork 100 UNT/ML Injectable Suspension	311053	RxNorm	NO	YES	NO

B.18.11 Concept: Metformin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1503297	metformin	6809	RxNorm	NO	YES	NO

B.18.12 Concept: Secondary diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
195771	Secondary diabetes mellitus	8801005	SNOMED	NO	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	NO	YES	NO

B.18.13 Concept: Type 1 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	NO	YES	NO
42689695	Eating disorder co-occurrent with diabetes mellitus type 1	1067201000000106	SNOMED	NO	YES	NO
765533	Glaucoma due to diabetes mellitus type 1	60981000119103	SNOMED	NO	YES	NO
43531006	Maturity onset diabetes of the young, type 1	609562003	SNOMED	NO	YES	NO
765650	Cranial nerve palsy due to diabetes mellitus type 1	82561000119101	SNOMED	NO	YES	NO
45770986	Retinopathy due to unstable diabetes mellitus type 1	706894000	SNOMED	NO	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	NO	YES	NO
45768456	Neuropathy due to unstable diabetes mellitus type 1	706891008	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	NO	YES	NO
4128019	Brittle type 1 diabetes mellitus	290002008	SNOMED	NO	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	NO	YES	NO

B.18.14 Concept: Type 2 diabetes mellitus

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
443238	Diabetic - poor control	268519009	SNOMED	NO	YES	NO
201820	Diabetes mellitus	73211009	SNOMED	NO	YES	NO
442793	Complication due to diabetes mellitus	74627003	SNOMED	NO	YES	NO
40484648	Type 1 diabetes mellitus uncontrolled	444073006	SNOMED	YES	YES	NO
201254	Type 1 diabetes mellitus	46635009	SNOMED	YES	YES	NO
435216	Disorder due to type 1 diabetes mellitus	420868002	SNOMED	YES	YES	NO
195771	Secondary diabetes mellitus	8801005	SNOMED	YES	YES	NO
761051	Complication due to secondary diabetes mellitus	138811000119100	SNOMED	YES	YES	NO
4016045	Diabetic - good control	170763003	SNOMED	NO	YES	NO
40484649	Type 1 diabetes mellitus well controlled	444074000	SNOMED	YES	YES	NO
43531009	Pregnancy and type 1 diabetes mellitus	609566000	SNOMED	YES	YES	NO
4024659	Gestational diabetes mellitus	11687002	SNOMED	YES	YES	NO

B.18.15 Concept: GLP-1 receptor agonists

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO
1583722	exenatide	60548	RxNorm	NO	YES	NO
40170911	liraglutide	475968	RxNorm	NO	YES	NO
44506754	lixisenatide	1440051	RxNorm	NO	YES	NO
793143	semaglutide	1991302	RxNorm	NO	YES	NO
44816332	albiglutide	1534763	RxNorm	NO	YES	NO

---

C Exposure Cohorts for SCCS

C.1 Semaglutide exposures

C.1.1 Cohort Entry Events

People enter the cohort when observing any of the following:

1. drug exposures of ‘semaglutide’.

C.1.2 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘semaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

C.1.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

C.1.4 Concept: semaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
793143	semaglutide	1991302	RxNorm	NO	YES	NO

---

C.2 Dulaglutide exposures

C.2.1 Cohort Entry Events

People enter the cohort when observing any of the following:

1. drug exposures of ‘dulaglutide’.

C.2.2 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘dulaglutide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

C.2.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

C.2.4 Concept: dulaglutide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774435	dulaglutide	1551291	RxNorm	NO	YES	NO

---

C.3 Exenatide exposures

C.3.1 Cohort Entry Events

People enter the cohort when observing any of the following:

1. drug exposures of ‘exenatide’.

C.3.2 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘exenatide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

C.3.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

C.3.4 Concept: exenatide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1583722	exenatide	60548	RxNorm	NO	YES	NO

---

C.4 Empagliflozin exposures

C.4.1 Cohort Entry Events

People enter the cohort when observing any of the following:

1. drug exposures of ‘empagliflozin’.

C.4.2 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘empagliflozin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

C.4.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

C.4.4 Concept: empagliflozin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45774751	empagliflozin	1545653	RxNorm	NO	YES	NO

---

C.5 Sitagliptin exposures

C.5.1 Cohort Entry Events

People enter the cohort when observing any of the following:

1. drug exposures of ‘sitagliptin’.

C.5.2 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘sitagliptin’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

C.5.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

C.5.4 Concept: sitagliptin

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1580747	sitagliptin	593411	RxNorm	NO	YES	NO

---

C.6 Glipizide exposures

C.6.1 Cohort Entry Events

People enter the cohort when observing any of the following:

1. drug exposures of ‘glipizide’.

C.6.2 Cohort Exit

The cohort end date will be based on a continuous exposure to ‘glipizide’: allowing 30 days between exposures, adding 0 days after exposure ends, and using days supply and exposure end date for exposure duration.

C.6.3 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

C.6.4 Concept: glipizide

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1560171	glipizide	4821	RxNorm	NO	YES	NO

---

D Outcome Cohorts

D.1 Specific NVAMD

D.1.1 Cohort Entry Events

People may enter the cohort when observing any of the following:

1. procedure occurrences of ‘[cxc] Intravitreal Injection’; having at least 1 drug exposure of ‘[cxc] anti-VEGF medication’, starting between 0 days before and 0 days after ‘[cxc] Intravitreal Injection’ start date.

D.1.2 Additional Inclusion Criteria

I. Has nvAMD diagnosis within 30 days of cohort entry

Entry events having at least 1 condition occurrence of ‘[cxc] exudative amd’, starting between 30 days before and 0 days after cohort entry start date.

II. Does not have nvAMD diagnosis beyond 30 days of cohort entry

Entry events having at least 0 condition occurrences of ‘[cxc] exudative amd’, starting anytime up to 30 days before cohort entry start date.

III. Age >55

Entry events with the following event criteria: who are > 55 years old. #### IV. Exclude other retinal diagnoses on index date {-}

Entry events with all of the following criteria:

1. having no condition occurrences of ‘[SOS] Macular edema’, starting between 0 days before and 0 days after cohort entry start date.
2. having no condition occurrences of ‘[SOS] Retinal Vein Occlusion’, starting between 0 days before and 0 days after cohort entry start date.

Limit qualifying entry events to the earliest event per person.

D.1.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.1.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.1.5 Concept: [cxc] Intravitreal Injection

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
2111025	Intravitreal injection of a pharmacologic agent (separate procedure)	67028	CPT4	NO	YES	NO
44806220	Intravitreal injection	800481000000101	SNOMED	NO	YES	NO
604986	Intravitreal injection of anti-vascular endothelial growth factor	1004045004	SNOMED	NO	YES	NO
4334590	Injection of drug into vitreous	231755001	SNOMED	NO	YES	NO

D.1.6 Concept: [cxc] anti-VEGF medication

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1397141	bevacizumab	253337	RxNorm	NO	YES	NO
19080982	ranibizumab	595060	RxNorm	NO	YES	NO
40244266	aflibercept	1232150	RxNorm	NO	YES	NO
1759013	faricimab	2591519	RxNorm	NO	YES	NO
37497314	brolucizumab	2204915	RxNorm	NO	YES	NO

D.1.7 Concept: [cxc] PDT

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
2111051	Destruction of localized lesion of choroid (eg, choroidal neovascularization); photodynamic therapy (includes intravenous infusion)	67221	CPT4	NO	YES	NO

D.1.8 Concept: [cxc] amd

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4294834	Choroidal retinal neovascularization	75971007	SNOMED	NO	YES	NO
4090255	Retinal drusen	247153005	SNOMED	NO	YES	NO
374028	Age related macular degeneration	267718000	SNOMED	NO	YES	NO
3662368	Bilateral neovascularization of choroid of eyes due to degenerative myopia	16837401000119105	SNOMED	YES	NO	NO
4225527	Calcified optic disc drusen	404656008	SNOMED	YES	NO	NO
4199039	Diffuse exudative maculopathy due to diabetes mellitus	314010006	SNOMED	YES	NO	NO
36684702	Drusen of left optic disc	339161000119107	SNOMED	YES	NO	NO
436701	Drusen of optic disc	33629003	SNOMED	YES	NO	NO
36713313	Histoplasmosis syndrome of bilateral eyes	677201000119104	SNOMED	YES	NO	NO
37109491	Histoplasmosis syndrome of left eye	677211000119101	SNOMED	YES	NO	NO
37109492	Histoplasmosis syndrome of right eye	677221000119108	SNOMED	YES	NO	NO
37116419	Myopic choroidal neovascularization	733124000	SNOMED	YES	NO	NO
4220147	Ocular histoplasmosis syndrome	416770009	SNOMED	YES	NO	NO
4082414	Optic disc drusen - buried	247227009	SNOMED	YES	NO	NO
4082413	Optic disc drusen - elevated	247226000	SNOMED	YES	NO	NO

D.1.9 Concept: [SOS] Macular edema

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4290333	Macular retinal edema	37231002	SNOMED	NO	YES	NO

D.1.10 Concept: [SOS] Retinal Vein Occlusion

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
440392	Retinal vascular occlusion	73757007	SNOMED	NO	YES	NO

D.1.11 Concept: [cxc] exudative amd

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
376966	Exudative age-related macular degeneration	414173003	SNOMED	NO	YES	NO
4199039	Diffuse exudative maculopathy due to diabetes mellitus	314010006	SNOMED	YES	NO	NO

D.1.12 Concept: diabetic retinopathy

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4174977	Retinopathy due to diabetes mellitus	4855003	SNOMED	NO	YES	NO

---

D.2 Sensitive NVAMD

D.2.1 Cohort Entry Events

People may enter the cohort when observing any of the following:

1. condition occurrences of ‘[cxc] exudative amd’.

D.2.2 Additional Inclusion Criteria

I. Age >55

Entry events with the following event criteria: who are > 55 years old. #### II. Exclude other retinal diagnoses on index date {-}

Entry events with all of the following criteria:

1. having no condition occurrences of ‘[SOS] Macular edema’, starting between 0 days before and 0 days after cohort entry start date.
2. having no condition occurrences of ‘[SOS] Retinal Vein Occlusion’, starting between 0 days before and 0 days after cohort entry start date.

Limit qualifying entry events to the earliest event per person.

D.2.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.2.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.2.5 Concept: [cxc] Intravitreal Injection

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
2111025	Intravitreal injection of a pharmacologic agent (separate procedure)	67028	CPT4	NO	YES	NO
44806220	Intravitreal injection	800481000000101	SNOMED	NO	YES	NO
604986	Intravitreal injection of anti-vascular endothelial growth factor	1004045004	SNOMED	NO	YES	NO
4334590	Injection of drug into vitreous	231755001	SNOMED	NO	YES	NO

D.2.6 Concept: [cxc] anti-VEGF medication

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
1397141	bevacizumab	253337	RxNorm	NO	YES	NO
19080982	ranibizumab	595060	RxNorm	NO	YES	NO
40244266	aflibercept	1232150	RxNorm	NO	YES	NO
1759013	faricimab	2591519	RxNorm	NO	YES	NO
37497314	brolucizumab	2204915	RxNorm	NO	YES	NO

D.2.7 Concept: [cxc] PDT

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
2111051	Destruction of localized lesion of choroid (eg, choroidal neovascularization); photodynamic therapy (includes intravenous infusion)	67221	CPT4	NO	YES	NO

D.2.8 Concept: [cxc] amd

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4294834	Choroidal retinal neovascularization	75971007	SNOMED	NO	YES	NO
4090255	Retinal drusen	247153005	SNOMED	NO	YES	NO
374028	Age related macular degeneration	267718000	SNOMED	NO	YES	NO
3662368	Bilateral neovascularization of choroid of eyes due to degenerative myopia	16837401000119105	SNOMED	YES	NO	NO
4225527	Calcified optic disc drusen	404656008	SNOMED	YES	NO	NO
4199039	Diffuse exudative maculopathy due to diabetes mellitus	314010006	SNOMED	YES	NO	NO
36684702	Drusen of left optic disc	339161000119107	SNOMED	YES	NO	NO
436701	Drusen of optic disc	33629003	SNOMED	YES	NO	NO
36713313	Histoplasmosis syndrome of bilateral eyes	677201000119104	SNOMED	YES	NO	NO
37109491	Histoplasmosis syndrome of left eye	677211000119101	SNOMED	YES	NO	NO
37109492	Histoplasmosis syndrome of right eye	677221000119108	SNOMED	YES	NO	NO
37116419	Myopic choroidal neovascularization	733124000	SNOMED	YES	NO	NO
4220147	Ocular histoplasmosis syndrome	416770009	SNOMED	YES	NO	NO
4082414	Optic disc drusen - buried	247227009	SNOMED	YES	NO	NO
4082413	Optic disc drusen - elevated	247226000	SNOMED	YES	NO	NO

D.2.9 Concept: [SOS] Macular edema

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4290333	Macular retinal edema	37231002	SNOMED	NO	YES	NO

D.2.10 Concept: [SOS] Retinal Vein Occlusion

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
440392	Retinal vascular occlusion	73757007	SNOMED	NO	YES	NO

D.2.11 Concept: [cxc] exudative amd

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
376966	Exudative age-related macular degeneration	414173003	SNOMED	NO	YES	NO
4199039	Diffuse exudative maculopathy due to diabetes mellitus	314010006	SNOMED	YES	NO	NO

D.2.12 Concept: diabetic retinopathy

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4174977	Retinopathy due to diabetes mellitus	4855003	SNOMED	NO	YES	NO

---

D.3 Non-infectious Ocular Inflammation

D.3.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘Non-infectious uveitis and scleritis’.

Limit cohort entry events to the earliest event per person.

D.3.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious uveitis and scleritis {-}

Entry events having at least 1 condition occurrence of ‘Non-infectious uveitis and scleritis’, starting between 30 days after and 365 days after cohort entry start date.

D.3.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.3.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.3.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
3657029	Bilateral superior limbic keratoconjunctivitis	343311000119109	SNOMED	YES	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	YES	YES	NO
40485977	Limbal vernal conjunctivitis	446021007	SNOMED	YES	YES	NO
4338874	Superior limbic keratoconjunctivitis	231903005	SNOMED	YES	YES	NO
3656945	Superior limbic keratoconjunctivitis of left eye	337521000119104	SNOMED	YES	YES	NO
3656861	Superior limbic keratoconjunctivitis of right eye	331901000119107	SNOMED	YES	YES	NO

D.3.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.3.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.3.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.3.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.3.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

D.4 Anterior Uveitis

D.4.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious anterior uveitis’.

Limit cohort entry events to the earliest event per person.

D.4.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious anterior uveitis {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious anterior uveitis’, starting between 30 days after and 365 days after cohort entry start date.

D.4.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.4.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.4.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.4.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.4.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.4.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.4.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

---

D.5 Chorioretinal Inflammation

D.5.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious chorioretinal inflammation’.

Limit cohort entry events to the earliest event per person.

D.5.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious chorioretinal inflammation {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious chorioretinal inflammation’, starting between 30 days after and 365 days after cohort entry start date.

D.5.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.5.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.5.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.5.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.5.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.5.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.5.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.5.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

D.6 Panuveitis

D.6.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious panuveitis’.

Limit cohort entry events to the earliest event per person.

D.6.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious panuveitis {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious panuveitis’, starting between 30 days after and 365 days after cohort entry start date.

D.6.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.6.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.6.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.6.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.6.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.6.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.6.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

---

D.7 Retinal Vasculitis

D.7.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious retinal vasculitis’.

Limit cohort entry events to the earliest event per person.

D.7.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious retinal vasculitis {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious retinal vasculitis’, starting between 30 days after and 365 days after cohort entry start date.

D.7.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.7.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.7.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.7.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.7.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.7.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.7.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

---

D.8 Non-infectious Ocular Inflammation excluding intraocular surgery

D.8.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘Non-infectious uveitis and scleritis’.

Limit cohort entry events to the earliest event per person.

D.8.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious uveitis and scleritis {-}

Entry events having at least 1 condition occurrence of ‘Non-infectious uveitis and scleritis’, starting between 30 days after and 365 days after cohort entry start date.

III. no intraocular surgery within 90 days prior to index

Entry events having at most 0 procedure occurrences of ‘intraocular surgery’, starting between 90 days before and 0 days after cohort entry start date.

D.8.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.8.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.8.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
3657029	Bilateral superior limbic keratoconjunctivitis	343311000119109	SNOMED	YES	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	YES	YES	NO
40485977	Limbal vernal conjunctivitis	446021007	SNOMED	YES	YES	NO
4338874	Superior limbic keratoconjunctivitis	231903005	SNOMED	YES	YES	NO
3656945	Superior limbic keratoconjunctivitis of left eye	337521000119104	SNOMED	YES	YES	NO
3656861	Superior limbic keratoconjunctivitis of right eye	331901000119107	SNOMED	YES	YES	NO

D.8.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.8.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.8.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.8.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.8.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

D.9 Anterior Uveitis excluding intraocular surgery

D.9.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious anterior uveitis’.

Limit cohort entry events to the earliest event per person.

D.9.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious anterior uveitis {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious anterior uveitis’, starting between 30 days after and 365 days after cohort entry start date.

III. no intraocular surgery within 90 days prior to index

Entry events having at most 0 procedure occurrences of ‘intraocular surgery’, starting between 90 days before and 0 days after cohort entry start date.

D.9.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.9.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.9.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.9.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.9.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.9.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.9.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.9.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

D.10 Chorioretinal Inflammation excluding intraocular surgery

D.10.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious chorioretinal inflammation’.

Limit cohort entry events to the earliest event per person.

D.10.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious chorioretinal inflammation {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious chorioretinal inflammation’, starting between 30 days after and 365 days after cohort entry start date.

III. no intraocular surgery within 90 days prior to index

Entry events having at most 0 procedure occurrences of ‘intraocular surgery’, starting between 90 days before and 0 days after cohort entry start date.

D.10.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.10.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.10.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.10.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.10.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.10.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.10.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.10.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

D.11 Panuveitis excluding intraocular surgery

D.11.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious panuveitis’.

Limit cohort entry events to the earliest event per person.

D.11.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious panuveitis {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious panuveitis’, starting between 30 days after and 365 days after cohort entry start date.

III. no intraocular surgery within 90 days

Entry events having at most 0 procedure occurrences of ‘intraocular surgery’, starting between 90 days before and 0 days after cohort entry start date.

D.11.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.11.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.11.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.11.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.11.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.11.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.11.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.11.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

D.12 Retinal Vasculitis excluding intraocular surgery

D.12.1 Cohort Entry Events

People with continuous observation of 90 days before event may enter the cohort when observing any of the following:

1. condition occurrences of ‘[trinetx] non-infectious retinal vasculitis’.

Limit cohort entry events to the earliest event per person.

D.12.2 Additional Inclusion Criteria

I. >= 18years old

Entry events with the following event criteria: who are >= 18 years old. #### II. 2nd Dx of Non-infectious retinal vasculitis {-}

Entry events having at least 1 condition occurrence of ‘[trinetx] non-infectious retinal vasculitis’, starting between 30 days after and 365 days after cohort entry start date.

III. no intraocular surgery within 90 days prior to index

Entry events having at most 0 procedure occurrences of ‘intraocular surgery’, starting between 90 days before and 0 days after cohort entry start date.

D.12.3 Cohort Exit

The person also exists the cohort at the end of continuous observation.

D.12.4 Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

D.12.5 Concept: Non-infectious uveitis and scleritis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4123081	Ocular sarcoidosis	234526006	SNOMED	NO	YES	NO
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4028363	Uveitis	128473001	SNOMED	NO	YES	NO
4090260	Subretinal fibrosis	247162007	SNOMED	NO	YES	NO
434944	Scleritis	78370002	SNOMED	NO	YES	NO
4195050	Uveitis related cystoid macular edema	312922007	SNOMED	NO	YES	NO
37311952	Glaucoma due to eye inflammation	788946007	SNOMED	NO	YES	NO
4143372	Scleritis and episcleritis	267659002	SNOMED	NO	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4132637	Infective scleritis	410578007	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
4224176	Tuberculous episcleritis	84288007	SNOMED	YES	YES	NO
4265441	Herpes simplex keratouveitis	397572000	SNOMED	YES	YES	NO
761312	Chorioretinitis of bilateral eyes caused by Toxoplasma gondii	15677721000119101	SNOMED	YES	YES	NO
761311	Chorioretinitis of left eye caused by Toxoplasma gondii	15677681000119107	SNOMED	YES	YES	NO
761313	Chorioretinitis of right eye caused by Toxoplasma gondii	15677761000119106	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
36687174	Uveitis of bilateral eyes caused by Toxoplasma gondii	15992911000119101	SNOMED	YES	YES	NO
36687176	Uveitis of left eye caused by Toxoplasma gondii	15992991000119105	SNOMED	YES	YES	NO
36687175	Uveitis of right eye caused by Toxoplasma gondii	15992951000119100	SNOMED	YES	YES	NO
432908	Glaucomatocyclitic crisis	29538005	SNOMED	YES	YES	NO
433765	Acute endophthalmitis	1493002	SNOMED	YES	YES	NO
434581	African histoplasmosis	78511005	SNOMED	YES	YES	NO
443867	Chronic endophthalmitis	13978000	SNOMED	YES	YES	NO
4322865	Congenital syphilitic choroiditis	9941009	SNOMED	YES	YES	NO
4251491	Congenital toxoplasmosis	73893000	SNOMED	YES	YES	NO
434570	Early congenital syphilis with symptoms	266125005	SNOMED	YES	YES	NO
438411	Endophthalmitis	1847009	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
434932	Fuchs’ heterochromic cyclitis	11226001	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
438961	Herpes zoster iridocyclitis	10698009	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373963	Histoplasma duboisii with retinitis	187049007	SNOMED	YES	YES	NO
433134	Histoplasmosis	12962009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
437214	Infection by Histoplasma capsulatum	76255006	SNOMED	YES	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4087751	Late congenital syphilitic oculopathy	186842007	SNOMED	YES	YES	NO
435739	Late syphilis	72083004	SNOMED	YES	YES	NO
375738	Neurosyphilis	26039008	SNOMED	YES	YES	NO
4132494	Ocular syphilis	410478005	SNOMED	YES	YES	NO
4166559	Ocular toxoplasmosis	416481006	SNOMED	YES	YES	NO
438738	Panophthalmitis	33382000	SNOMED	YES	YES	NO
440715	Parasitic endophthalmitis	57100005	SNOMED	YES	YES	NO
37161477	Perinatal infection of fetus and/or neonate	1179410005	SNOMED	YES	YES	NO
432621	Purulent endophthalmitis	41720003	SNOMED	YES	YES	NO
434274	Secondary syphilitic chorioretinitis	66281009	SNOMED	YES	YES	NO
439731	Secondary syphilitic iridocyclitis	30080002	SNOMED	YES	YES	NO
42536584	Symptomatic late congenital syphilis	735515000	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
374270	Tuberculosis of eye	49107007	SNOMED	YES	YES	NO
4087293	Tuberculous chorioretinitis	186263000	SNOMED	YES	YES	NO
439671	Uveitis due to secondary syphilis	186854007	SNOMED	YES	YES	NO
373464	Vitreous abscess	48142003	SNOMED	YES	YES	NO
3656995	Fuchs’ heterochromic cyclitis of left eye	340671000119102	SNOMED	YES	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
4334873	Toxocara chorioretinitis	231994007	SNOMED	YES	YES	NO
45757253	Herpes zoster scleritis	1087131000119102	SNOMED	YES	YES	NO
4198121	Tuberculous uveitis	314029000	SNOMED	YES	YES	NO
444087	Syphilitic episcleritis	11338007	SNOMED	YES	YES	NO
4134613	Eye infection	128351009	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO
4208666	Viral eye infection	312132001	SNOMED	YES	YES	NO
4327334	Infection by Ophryoscolex	75070005	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
4132493	Infective uveitis	410477000	SNOMED	YES	YES	NO
37311893	Posterior uveitis due to infectious disease	789008006	SNOMED	YES	YES	NO
4109415	Secondary infected iridocyclitis	193487008	SNOMED	YES	YES	NO
762971	Secondary infective uveitis	434391000124109	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
45757696	Syphilitic choroiditis	331151000119109	SNOMED	YES	YES	NO
438971	Syphilitic disseminated retinochoroiditis	77939001	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
4196116	Tertiary syphilitic chorioretinitis	312955002	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO

D.12.6 Concept: [trinetx] non-infectious chorioretinal inflammation

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
4161546	Retinitis	399463004	SNOMED	NO	YES	NO
4042904	Choroiditis	16553002	SNOMED	NO	YES	NO
4335988	Bacterial chorioretinitis	231988004	SNOMED	YES	YES	NO
439736	Focal chorioretinitis due to acquired toxoplasmosis	88290000	SNOMED	YES	YES	NO
4234762	Parasitic chorioretinitis	359698000	SNOMED	YES	YES	NO
4195054	Syphilitic chorioretinitis	312934004	SNOMED	YES	YES	NO
4090114	Toxoplasmosis chorioretinitis	187194004	SNOMED	YES	YES	NO
4230365	Parasitic choroiditis	359695002	SNOMED	YES	YES	NO
45757694	Toxoplasma choroiditis	331101000119105	SNOMED	YES	YES	NO
4230371	Fungal chorioretinitis	359707007	SNOMED	YES	YES	NO
4230369	Fungal choroiditis	359702001	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
4218993	Mycobacterium avium intracellulare group choroiditis	417115008	SNOMED	YES	YES	NO
46273984	Cytomegalovirus chorioretinitis	711616006	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3663239	Panuveitis caused by virus	870329005	SNOMED	YES	YES	NO
4338889	Acute retinal necrosis	231986000	SNOMED	YES	YES	NO
4330151	Cytomegaloviral retinitis	22455005	SNOMED	YES	YES	NO
378078	Histoplasma capsulatum with retinitis	187039009	SNOMED	YES	YES	NO
373972	Histoplasmosis with retinitis	187058000	SNOMED	YES	YES	NO
435269	Optic papillitis	73221001	SNOMED	YES	YES	NO
4211820	Toxoplasma retinitis	416589006	SNOMED	YES	YES	NO
4334872	Viral retinitis	231984002	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO

D.12.7 Concept: [trinetx] non-infectious anterior uveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
433187	Cyclitis	17657000	SNOMED	NO	YES	NO
439018	Hypopyon	87807004	SNOMED	NO	YES	NO
434029	Chronic anterior uveitis	398155003	SNOMED	NO	YES	NO
4176864	Acute anterior uveitis	4927003	SNOMED	NO	YES	NO
4274964	Iritis	65074000	SNOMED	NO	YES	NO
440716	Infectious secondary iridocyclitis	89114005	SNOMED	YES	YES	NO
444446	Gonococcal iridocyclitis	9091006	SNOMED	YES	YES	NO
46269950	Iridocyclitis caused by tuberculosis	1092761000119105	SNOMED	YES	YES	NO
4221343	Herpetic iridocyclitis	420485005	SNOMED	YES	YES	NO
440634	Herpes simplex iridocyclitis	13608004	SNOMED	YES	YES	NO
761321	Iridocyclitis of left eye due to herpes zoster	15678801000119102	SNOMED	YES	YES	NO
432640	Hypopyon ulcer	6395007	SNOMED	YES	YES	NO
603297	Bilateral iritis of eyes caused by Human alphaherpesvirus	15679281000119103	SNOMED	YES	YES	NO
608988	Bilateral iritis of eyes caused by Human alphaherpesvirus 3	15991751000119109	SNOMED	YES	YES	NO
761322	Iritis of left eye caused by herpes simplex virus	15679241000119108	SNOMED	YES	YES	NO
37209448	Iritis of left eye caused by herpes zoster virus	15991791000119104	SNOMED	YES	YES	NO
761323	Iritis of right eye caused by herpes simplex virus	15679321000119108	SNOMED	YES	YES	NO
37209447	Iritis of right eye caused by herpes zoster virus	15991711000119108	SNOMED	YES	YES	NO
37311935	Infectious intermediate uveitis	788963006	SNOMED	YES	YES	NO
45757573	Infectious secondary iritis	220101000119108	SNOMED	YES	YES	NO
37161128	Syphilitic infectious intermediate uveitis	1177029002	SNOMED	YES	YES	NO
4197155	Intermediate uveitis	314429009	SNOMED	YES	YES	NO
4072340	Herpes simplex iritis	20555001	SNOMED	YES	YES	NO
45770924	Herpes zoster iritis	331071000119101	SNOMED	YES	YES	NO
37169450	Bilateral iritis due to secondary syphilis	15993471000119105	SNOMED	YES	YES	NO
37169449	Left iritis due to secondary syphilis	15993351000119107	SNOMED	YES	YES	NO
37169448	Right iritis due to secondary syphilis	15993311000119106	SNOMED	YES	YES	NO
46273126	Syphilitic iritis	711617002	SNOMED	YES	YES	NO
45757712	Gonococcal iritis	342381000119109	SNOMED	YES	YES	NO

D.12.8 Concept: [trinetx] non-infectious panuveitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
439014	Panuveitis	75614007	SNOMED	NO	YES	NO
37161127	Bacterial panuveitis	1177028005	SNOMED	YES	YES	NO
37161097	Fungal panuveitis	1176990003	SNOMED	YES	YES	NO
37312551	Infectious panuveitis	789116000	SNOMED	YES	YES	NO
3655858	Panuveitis caused by Borrelia burgdorferi	870335005	SNOMED	YES	YES	NO
3655855	Panuveitis caused by Herpesvirus	870332008	SNOMED	YES	YES	NO
3655856	Panuveitis caused by Mycobacterium tuberculosis	870333003	SNOMED	YES	YES	NO
3655853	Panuveitis caused by parasite	870330000	SNOMED	YES	YES	NO
3655854	Panuveitis caused by Treponema pallidum	870331001	SNOMED	YES	YES	NO

D.12.9 Concept: [trinetx] non-infectious retinal vasculitis

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
436403	Retinal vasculitis	77628002	SNOMED	NO	YES	NO

D.12.10 Concept: intraocular surgery

Concept ID	Concept Name	Code	Vocabulary	Excluded	Descendants	Mapped
45888816	Procedures on the Lens of the Eye	1009869	CPT4	NO	YES	YES
2110922	Removal of foreign body, intraocular; from posterior segment, nonmagnetic extraction	65265	CPT4	NO	YES	YES
42628005	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; initial device	0449T	CPT4	NO	YES	NO
2110944	Keratoplasty (corneal transplant); endothelial	65756	CPT4	NO	YES	YES
4150502	Paracentesis of anterior chamber of eye	31222007	SNOMED	NO	YES	NO
42628006	Insertion of aqueous drainage device, without extraocular reservoir, internal approach, into the subconjunctival space; each additional device (List separately in addition to code for primary procedure)	0450T	CPT4	NO	YES	NO
45888542	Removal of foreign body, intraocular	1009757	CPT4	NO	YES	YES
45888690	Intraocular Lens Procedures	1018495	CPT4	NO	YES	YES
40757013	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); with retention of device or stent	66175	CPT4	NO	YES	NO
42628009	Insertion of anterior segment aqueous drainage device, with creation of intraocular reservoir, internal approach, into the supraciliary space	0474T	CPT4	NO	YES	NO
2110957	Paracentesis of anterior chamber of eye (separate procedure); with therapeutic release of aqueous (Deprecated)	65805	CPT4	NO	YES	NO
2110943	Keratoplasty (corneal transplant); penetrating (in pseudophakia)	65755	CPT4	NO	YES	YES
40757003	Transluminal dilation of aqueous outflow canal (eg, canaloplasty); without retention of device or stent	66174	CPT4	NO	YES	NO
4328205	Operative procedure on anterior segment of eye	75787004	SNOMED	NO	YES	NO
2111028	Vitrectomy, mechanical, pars plana approach	67036	CPT4	NO	YES	YES
46257632	Revision of aqueous shunt to extraocular equatorial plate reservoir; without graft	66184	CPT4	NO	YES	NO
45890409	Procedures on the Iris, Ciliary Body of the Eye	1009844	CPT4	NO	YES	YES
4169582	Removal of foreign body from posterior segment of eye	48933009	SNOMED	NO	YES	NO
2110920	Removal of foreign body, intraocular; from anterior chamber of eye or lens	65235	CPT4	NO	YES	YES
45890181	Keratoplasty (corneal transplant)	1009787	CPT4	NO	YES	YES
2110942	Keratoplasty (corneal transplant); penetrating (in aphakia)	65750	CPT4	NO	YES	YES
2110981	Aqueous shunt to extraocular equatorial plate reservoir, external approach; with graft	66180	CPT4	NO	YES	NO
45889175	Repair Procedures on the Retina or Choroid	1009908	CPT4	NO	YES	YES
45888921	Vitreous Procedures on the Posterior Segment of the Eye	1009893	CPT4	NO	YES	YES
42734160	Vitrectomy, mechanical, pars plana approach; with epiretinal membrane stripping (Deprecated)	67038	CPT4	NO	YES	NO
46257725	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, internal approach, into the trabecular meshwork; each additional device insertion (List separately in addition to code for primary procedure) (Deprecated)	0376T	CPT4	NO	YES	NO
2111020	Removal of vitreous, anterior approach (open sky technique or limbal incision); partial removal	67005	CPT4	NO	YES	YES
2110921	Removal of foreign body, intraocular; from posterior segment, magnetic extraction, anterior or posterior route	65260	CPT4	NO	YES	YES
2738962	Drainage of Right Vitreous, Percutaneous Approach, Diagnostic	08943ZX	ICD10PCS	NO	YES	NO
46257451	Aqueous shunt to extraocular equatorial plate reservoir, external approach; without graft	66179	CPT4	NO	YES	NO
4288992	Implantation of prosthetic intraocular lens	69724002	SNOMED	NO	YES	NO
4066998	Operative procedure on posterior segment of eye	17348004	SNOMED	NO	YES	NO
2111018	Use of ophthalmic endoscope (List separately in addition to code for primary procedure)	66990	CPT4	NO	YES	NO
45888590	Procedures on the Anterior Chamber of the Eye	1009804	CPT4	NO	YES	YES
4185759	Injection of anterior chamber of eye	4143006	SNOMED	NO	YES	NO
4218754	Injection of posterior segment of eye	82036007	SNOMED	NO	YES	NO
2111021	Removal of vitreous, anterior approach (open sky technique or limbal incision); subtotal removal with mechanical vitrectomy	67010	CPT4	NO	YES	YES
2111017	Exchange of intraocular lens	66986	CPT4	NO	YES	YES
44816348	Insertion of anterior segment aqueous drainage device, without extraocular reservoir, external approach	66183	CPT4	NO	YES	NO
2111004	Discission of secondary membranous cataract (opacified posterior lens capsule and/or anterior hyaloid); laser surgery (eg, YAG laser) (1 or more stages)	66821	CPT4	YES	NO	NO
2111000	Iridotomy/iridectomy by laser surgery (eg, for glaucoma) (per session)	66761	CPT4	YES	NO	NO
2110963	Severing adhesions of anterior segment, laser technique (separate procedure)	65860	CPT4	YES	NO	NO
2111027	Severing of vitreous strands, vitreous face adhesions, sheets, membranes or opacities, laser surgery (1 or more stages)	67031	CPT4	YES	NO	NO
2110962	Trabeculoplasty by laser surgery	65855	CPT4	YES	NO	NO

---

E Negative Control Concepts

Table E.1: Negative outcome controls specified through condition occurrences that map to (a descendent of) the indicated concept ID

	Concept ID
439935	Abnormal posture
443585	Abrasion and/or friction burn of multiple sites
199192	Abrasion and/or friction burn of trunk without infection
4088290	Absence of breast
4092879	Absent kidney
75911	Acquired hallux valgus
137951	Acquired keratoderma
73241	Anal and rectal polyp
45757682	Anomaly of jaw size
81878	Benign paroxysmal positional vertigo
4216219	Bizarre personal appearance
133655	Burn of forearm
134765	Cachexia
73560	Calcaneal spur
434327	Cannabis abuse
140842	Changes in skin texture
81378	Chondromalacia of patella
432303	Cocaine abuse
4201390	Colostomy present
46269889	Complication due to Crohn’s disease
434675	Complication of gastrostomy
134438	Contact dermatitis
78619	Contusion of knee
201606	Crohn’s disease
76786	Derangement of knee
436077	Developmental delay
377910	Deviated nasal septum
4115402	Difficulty sleeping
45757370	Disproportion of reconstructed breast
433111	Effects of hunger
433527	Endometriosis
4170770	Epidermoid cyst
437448	Exhaustion due to excessive exertion
4092896	Feces contents abnormal
4092896	Feces contents abnormal
374801	Foreign body in ear
259995	Foreign body in orifice
4096540	Foreskin deficient
439788	Galactosemia
40481632	Ganglion cyst
40481632	Ganglion cyst
4168318	Genetic disorder carrier
433577	Hammer toe
4231770	Hereditary thrombophilia
4012570	High risk sexual behavior
4012934	Homocystinuria
374375	Impacted cerumen
374375	Impacted cerumen
4344500	Impingement syndrome of shoulder region
40481897	Inadequate sleep hygiene
139099	Ingrowing nail
444132	Injury of knee
4265896	Jellyfish poisoning
432593	Kwashiorkor
434203	Late effect of contusion
438329	Late effect of motor vehicle accident
4027782	Lipid storage disease
433997	Lymphangioma
4051630	Malingering
258540	Marfan’s syndrome
432798	Mechanical complication of internal orthopedic device, implant AND/OR graft
4103703	Melena
439795	Minimal cognitive impairment
4209423	Nicotine dependence
4209423	Nicotine dependence
377572	Noise effects on inner ear
136368	Non-toxic multinodular goiter
40480893	Nonspecific tuberculin test reaction
40480893	Nonspecific tuberculin test reaction
438130	Opioid abuse
438130	Opioid abuse
4299094	Opioid intoxication
4091513	Passing flatus
437092	Physiological development failure
433951	Poisoning by tranquilizer
4202045	Postviral fatigue syndrome
439790	Psychalgia
81634	Ptotic breast
380706	Regular astigmatism
141932	Senile hyperkeratosis
4019836	Social exclusion
36713918	Somatic dysfunction of lumbar region
443172	Splinter of face without major open wound
81151	Sprain of ankle
72748	Strain of rotator cuff capsule
432436	Symbolic dysfunction
378427	Tear film insufficiency
437264	Tobacco dependence syndrome
433244	Tooth loss
436876	Toxic effect of lead compound
440612	Toxic effect of tobacco and nicotine
4201387	Tracheostomy present
45757285	Unsatisfactory tooth restoration
140641	Verruca vulgaris
4115367	Wrist joint pain
440193	Wristdrop