Protocol: Learning curve for local Vs federated Vs transfer learning

Published

September 17, 2026

Info

Research Area: Methods research
Protocol Version: 1.0.0

Research Question

What is the best strategy for model development when an outcome is rare and data are spread out across different sites? Should you do local model vs federated learning vs transfer learning? Is there a cetain data size/outcome count where one approach is better than others?

Lay Summary

Objective

We will compare three ways of building clinical prediction models: training a model using data from a single site (“local”), training across sites without sharing patient-level data (“federated”), and starting from a shared model then adapting it to a single site (“fine-tuning”). We will see how each performs as the amount of available data grows.

Design overview

For a range of prediction tasks and for different training set sizes (from small to large), we will create learning curves showing model performance as more data is used. All participating sites will map their records to the OMOP Common Data Model so data inputs are consistent across sites.

What we will measure (in plain language)

Discrimination: how well the model tells apart people who do and do not experience the outcome (higher discrimination means better risk ranking).
Calibration: whether the model’s probability estimates match what actually happens (good calibration means a 10% predicted risk corresponds to ~10% observed).
Stability: how reliable the model is when applied to new sites or new time periods - that is, how much performance varies across different settings or over time.

Why this matters

Different training strategies have trade-offs. Local models are simple but may suffer when local data are scarce. Federated learning can leverage information across sites while preserving privacy, but is more complex. Fine-tuning a shared model may combine the best of both approaches. The learning curves will show at what data sizes each approach gives the best combination of accuracy, well-calibrated risk estimates, and consistency.

Expected impact

Results will help clinicians, data scientists, and healthcare organizations choose the most appropriate development strategy depending on how much data they have and their privacy constraints. This will guide practical decisions about when to invest in federated infrastructure versus building or fine-tuning local models.

Technical Summary

Objective

Compare three model-development strategies - local training, federated training, and fine-tuning - across four clinical prediction tasks and a range of training-data sizes to produce learning curves that quantify discrimination, calibration, and stability as data size increases.

Prediction tasks

Stroke within 1 year of initial atrial fibrillation (common outcome).
Death within 1 year of initial quadriplegia (rare population).
Lung cancer within 3 years after an outpatient visit in patients cancer-free at that visit (rare outcome).
Hospitalization after outpatient COVID diagnosis (emerging task with small early-data regime).

Data sources and mapping

Development: five US databases mapped to OMOP CDM - CCAE, MDCD, MDCR, Optum Clinformatics (claims), and Optum EHR (EHR). External validation: all additional OMOP-mapped databases available in the network (denoted N external databases).

Modeling framework

For model features/covaraites we will use one-hot encoded features representing whether a patient had a drug or condition recorded in the prior 1-year for all drugs/conditions recorded in the databases plus age at index, sex and number of visit per visit type as covariates.

Base model class: L1-regularized logistic regression (lasso) for all approaches to ensure comparability. Hyperparameters (regularization strength) chosen by internal cross-validation within each training sample.

We will hold out 25% of the full database as a constant test set across methods and data samples.

Sampling design 1 (by outcome)

Per database, draw random samples that contain a fixed number of outcome events: nout ∈ {25,50,100,150,200,500,1000}.

For each sampled set of outcomes, sample each database randomly until there are nout outcomes (this preserves oucome rate); document actual prevalence used.

Repeat the random sampling procedure multiple times (e.g., 20 independent repeats) to estimate variability and support stability analyses. Use consistent random seeds across methods for comparability.

Sampling design 2 (by target percentage)

Per database, draw a random pout percent sample: pout ∈ {10%, 20%, 30%, 40%, 50%, 60%, 70%}.

This results in different database samples across the data network which is commonly observed in reality.

Three development strategies

Local models

Each database trains a lasso logistic regression using only its sampled data (for each nout). Performance assessed on a held-out internal test split from the same database.

Federated models

For each sampling level, each development database trains a local lasso model on its sampled data.

Combine local models by coefficient averaging: coefficients are averaged across sites with weights proportional to site sample size to produce a federated model for that nout level. (All sites use the same per-database nout in a federated run.)

No patient-level data leave sites; only model coefficients and minimal metadata are shared.

Fine-tuned models

For each target/local database and each nout: (a) pretrain an aggregated model on the sampled data from the other development databases (using federated averaging across those databases); (b) fine-tune the pretrained/aggregated model on the local database’s sampled data to produce the final local-adapted model. Fine-tuning re-estimates coefficients using the local sample with the aggregated model as initialization and with potentially reduced regularization.

Internal and external evaluation

Internal: For each run, withhold an internal test set from the local database not used in training (e.g., 25% holdout) to estimate within-site performance.
External: Validate every model (local, federated, fine-tuned) across the N external OMOP-mapped databases in a network validation study.

Performance metrics and stability

Discrimination: AUC (ROC), and area under the precision-recall curve (AUPRC) for rare outcomes.
Calibration: calibration-in-the-large, calibration slope, calibration plots, and Brier score. Consider calibration error summaries (e.g., ECE).
Stability / robustness: quantify variability of discrimination and calibration across (a) sampling repeats, (b) development databases, and (c) external validation sites. Report standard deviations, 95% confidence intervals (bootstrap), and ranges. Also present learning-curve summaries (metric vs. nout) with uncertainty bands.

Reporting and comparisons

Produce learning curves for each task and each approach (local, federated, fine-tuned) plotting median metric and 95% CI vs. nout.
Compare approaches at each nout using pre-specified criteria (e.g., non-overlapping CIs, pre-defined performance differences) and report thresholds where one approach consistently outperforms others.
Report per-site and pooled external validation results to characterize transportability.

Operational details and reproducibility

Ensure identical covariate definitions, preprocessing pipelines, and model fitting code across sites.
Use the same random seeds for sampling across methods to improve comparability.
Save and report model hyperparameters, sample sizes, and the number of repeats.
Document any deviations (e.g., inability to reach desired nout in a database) and handle via prespecified rules (e.g., exclude that sampling level for that database or use maximum available events).

Summary

This study will generate task-specific learning curves for local, federated, and fine-tuned lasso logistic regression models across a range of outcome counts using OMOP-standardized data, and will evaluate discrimination, calibration, and stability internally and across external OMOP databases to identify data-size regimes where one strategy is preferable.

Phenotypes

The definitions via human readable descriptions in addition to SQL and JSON representations are available below.

Target Cohorts

[PL] Earliest event of Atrial Fibrillation

Cohort Entry Events

People enter the cohort when observing any of the following:

condition occurrence of ‘Atrial fibrillation’ for the first time in the person’s history.

Limit cohort entry events to the earliest event per person.

Cohort Exit

The person exits the cohort at the end of continuous observation.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

{ “cdmVersionRange” : “>=5.0.0”, “PrimaryCriteria” : { “CriteriaList” : [ { “ConditionOccurrence” : { “CodesetId” : 3, “First” : true } } ], “ObservationWindow” : { “PriorDays” : 0, “PostDays” : 0 }, “PrimaryCriteriaLimit” : { “Type” : “First” } }, “ConceptSets” : [ { “id” : 3, “name” : “Atrial fibrillation”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 313217, “CONCEPT_NAME” : “Atrial fibrillation”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “49436004”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4068155, “CONCEPT_NAME” : “Atrial arrhythmia”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “17366009”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false } ] } } ], “QualifiedLimit” : { “Type” : “First” }, “ExpressionLimit” : { “Type” : “First” }, “InclusionRules” : [], “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 0 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 3 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (313217,4068155)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (313217))

) I ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date , row_number() over (PARTITION BY co.person_id ORDER BY co.condition_start_date, co.condition_occurrence_id) as ordinal FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

WHERE C.ordinal = 1 – End Condition Occurrence Criteria

) E JOIN @cdm_database_schema.observation_period OP on E.person_id = OP.person_id and E.start_date >= OP.observation_period_start_date and E.start_date <= op.observation_period_end_date WHERE DATEADD(day,0,OP.OBSERVATION_PERIOD_START_DATE) <= E.START_DATE AND DATEADD(day,0,E.START_DATE) <= OP.OBSERVATION_PERIOD_END_DATE ) P WHERE P.ordinal = 1 – End Primary Events ) pe

) QE

;

— Inclusion Rule Inserts

create table #inclusion_events (inclusion_rule_id bigint, person_id bigint, event_id bigint );

select event_id, person_id, start_date, end_date, op_start_date, op_end_date into #included_events FROM ( SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, row_number() over (partition by person_id order by start_date ASC) as ordinal from ( select Q.event_id, Q.person_id, Q.start_date, Q.end_date, Q.op_start_date, Q.op_end_date, SUM(coalesce(POWER(cast(2 as bigint), I.inclusion_rule_id), 0)) as inclusion_rule_mask from #qualified_events Q LEFT JOIN #inclusion_events I on I.person_id = Q.person_id and I.event_id = Q.event_id GROUP BY Q.event_id, Q.person_id, Q.start_date, Q.end_date, Q.op_start_date, Q.op_end_date ) MG – matching groups

) Results WHERE Results.ordinal = 1 ;

– generate cohort periods into #final_cohort select person_id, start_date, end_date INTO #cohort_rows from ( – first_ends select F.person_id, F.start_date, F.end_date FROM ( select I.event_id, I.person_id, I.start_date, CE.end_date, row_number() over (partition by I.person_id, I.event_id order by CE.end_date) as ordinal from #included_events I join ( – cohort_ends – cohort exit dates – By default, cohort exit at the event’s op end date select event_id, person_id, op_end_date as end_date from #included_events ) CE on I.event_id = CE.event_id and I.person_id = CE.person_id and CE.end_date >= I.start_date ) F WHERE F.ordinal = 1 ) FE;

select person_id, min(start_date) as start_date, DATEADD(day,-1 * 0, max(end_date)) as end_date into #final_cohort from ( select person_id, start_date, end_date, sum(is_start) over (partition by person_id order by start_date, is_start desc rows unbounded preceding) group_idx from ( select person_id, start_date, end_date, case when max(end_date) over (partition by person_id order by start_date rows between unbounded preceding and 1 preceding) >= start_date then 0 else 1 end is_start from ( select person_id, start_date, DATEADD(day,0,end_date) as end_date from #cohort_rows ) CR ) ST ) GR group by person_id, group_idx;

DELETE FROM @target_database_schema.@target_cohort_table where cohort_definition_id = @target_cohort_id; INSERT INTO @target_database_schema.@target_cohort_table (cohort_definition_id, subject_id, cohort_start_date, cohort_end_date) select @target_cohort_id as cohort_definition_id, person_id, start_date, end_date FROM #final_cohort CO ;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

tetraplegia specific

Cohort Entry Events

People may enter the cohort when observing any of the following:

condition occurrences of ‘tetraplegia specific’.

Limit cohort entry events to the earliest event per person.

Inclusion Criteria

1. 1 year prior obs

Entry events having at least 1 observation period, starting anytime up to 365 days before cohort entry start date.

Cohort Exit

The person exits the cohort at the end of continuous observation.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

{ “cdmVersionRange” : “>=5.0.0”, “PrimaryCriteria” : { “CriteriaList” : [ { “ConditionOccurrence” : { “CodesetId” : 1 } } ], “ObservationWindow” : { “PriorDays” : 0, “PostDays” : 0 }, “PrimaryCriteriaLimit” : { “Type” : “First” } }, “ConceptSets” : [ { “id” : 1, “name” : “tetraplegia specific”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 40480416, “CONCEPT_NAME” : “Complete tetraplegia due to lesion at C1-C4 level”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “441705005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 40481376, “CONCEPT_NAME” : “Complete tetraplegia due to lesion at C5-C7 level”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “441980007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } } ], “QualifiedLimit” : { “Type” : “First” }, “ExpressionLimit” : { “Type” : “First” }, “InclusionRules” : [ { “name” : “1 year prior obs”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ObservationPeriod” : {} }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 365, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } } ], “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 0 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 1 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (40480416,40481376)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (40480416,40481376))

) I ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 1) ) C

– End Condition Occurrence Criteria

) QE

;

— Inclusion Rule Inserts

select 0 as inclusion_rule_id, person_id, event_id INTO #Inclusion_0 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

from ( select op.person_id,op.observation_period_id,op.period_type_concept_id,op.observation_period_start_date as start_date, op.observation_period_end_date as end_date , row_number() over (PARTITION BY op.person_id ORDER BY op.observation_period_start_date) as ordinal FROM @cdm_database_schema.OBSERVATION_PERIOD op ) C

– End Observation Period Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,-365,P.START_DATE) ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 1 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id AND AC.event_id = pe.event_id ) Results ;

SELECT inclusion_rule_id, person_id, event_id INTO #inclusion_events FROM (select inclusion_rule_id, person_id, event_id from #Inclusion_0) I; TRUNCATE TABLE #Inclusion_0; DROP TABLE #Inclusion_0;

– the matching group with all bits set ( POWER(2,# of inclusion rules) - 1 = inclusion_rule_mask WHERE (MG.inclusion_rule_mask = POWER(cast(2 as bigint),1)-1)

) Results WHERE Results.ordinal = 1 ;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

[Lung Cancer Prediction] Validation T 2017 Lung cancer (no prior cancer)

Cohort Entry Events

People with continuous observation of 365 days before event may enter the cohort when observing any of the following:

visit occurrences of ‘[standardized] outpatient visit’, who are between 45 and 65 years old; starting between January 1, 2017 and December 31, 2017.

Limit cohort entry events to the earliest event per person.

Inclusion Criteria

1. No prior lung cancer

Entry events with all of the following criteria:

having no condition occurrences of ‘All Lung Cancer broad’, starting anytime on or before cohort entry start date.
having no observations of ‘history of lung cancer’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘All Lung Cancer broad’, starting anytime on or before cohort entry start date.
having no measurements of ‘All Lung Cancer broad’, starting anytime on or before cohort entry start date.
having no observations of ‘All Lung Cancer broad’, starting anytime on or before cohort entry start date.

2. No prior cancer

Entry events with all of the following criteria:

having no condition occurrences of ‘Malignancy excluding non-melanoma skin cancer’, starting anytime on or before cohort entry start date; with all of the following criteria:
1. having no condition occurrences of ‘Malignancy excluding non-melanoma skin cancer’ (including ‘icd10 to ignore from 22’ source concepts), starting between 0 days before and 0 days after ‘Malignancy excluding non-melanoma skin cancer’ start date.
2. having no condition occurrences of ‘Malignancy excluding non-melanoma skin cancer’ (including ‘icd9 to ignore from 22’ source concepts), starting between 0 days before and 0 days after ‘Malignancy excluding non-melanoma skin cancer’ start date.
having no observations of ‘Malignancy excluding non-melanoma skin cancer’, starting anytime on or before cohort entry start date; with all of the following criteria:
1. having no observations of ‘Malignancy excluding non-melanoma skin cancer’ (including ‘icd10 to ignore from 22’ source concepts), starting between 0 days before and 0 days after ‘Malignancy excluding non-melanoma skin cancer’ start date.
2. having no observations of ‘Malignancy excluding non-melanoma skin cancer’ (including ‘icd9 to ignore from 22’ source concepts), starting between 0 days before and 0 days after ‘Malignancy excluding non-melanoma skin cancer’ start date.

3. No prior chemo

Entry events with all of the following criteria:

having no drug exposures of ‘chemo’, starting anytime on or before cohort entry start date.
having no observations of ‘chemo’, starting anytime on or before cohort entry start date.
having no device exposures of ‘chemo’, starting anytime on or before cohort entry start date.

4. No prior LC symptoms

Entry events having no condition occurrences of ‘symptoms’, starting anytime on or before cohort entry start date.

5. No prior initial diagnostic imaging

Entry events with all of the following criteria:

having no procedure occurrences of ‘[Lung Cancer JMR] Low Dose CT Screening’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘[Lung Cancer JMR] CHEST XRAY’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘[Lung Cancer JMR] CHEST CT SCANS’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘[Lung Cancer JMR] screen diagnosis’, starting anytime on or before cohort entry start date.
having no condition occurrences of ‘[Lung Cancer JMR] abnormal image’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘[Lung Cancer JMR] MRI for chest’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘[Lung Cancer JMR] INTERESTING CPT CODE TO WATCH FOR’, starting anytime on or before cohort entry start date.

6. No prior Confirmatory Imaging

Entry events with all of the following criteria:

having no procedure occurrences of ‘[Lung Cancer JMR] Confirmatory Imaging’, starting anytime on or before cohort entry start date.
having no observations of ‘[Lung Cancer JMR] Confirmatory Imaging’, starting anytime on or before cohort entry start date.

7. No prior Biopsy Bronchoscopy

Entry events having no procedure occurrences of ‘Biopsy Bronchoscopy’, starting anytime on or before cohort entry start date.

8. No prior Add on procedures - biopsy

Entry events with all of the following criteria:

having no measurements of ‘Add on procedures - biopsy’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘Add on procedures - biopsy’, starting anytime on or before cohort entry start date.

9. No prior Biopsy TTNA

Entry events having no procedure occurrences of ‘Biopsy TTNA’, starting anytime on or before cohort entry start date.

10. No prior Thoracic Surgery

Entry events with all of the following criteria:

having no procedure occurrences of ‘Thoracic Surgery’, starting anytime on or before cohort entry start date.
having no observations of ‘Thoracic Surgery’, starting anytime on or before cohort entry start date.

11. No prior radiation

Entry events with all of the following criteria:

having no device exposures of ‘Radiation’, starting anytime on or before cohort entry start date.
having no drug eras of ‘Radiation’, starting anytime on or before cohort entry start date.
having no procedure occurrences of ‘Radiation’, starting anytime on or before cohort entry start date.
having no measurements of ‘Radiation’, starting anytime on or before cohort entry start date.

12. No prior biopsy surgery

Entry events having no procedure occurrences of ‘biopsy surgery’, starting anytime on or before cohort entry start date.

13. No prior ablation

Entry events having no procedure occurrences of ‘No prior ablation’, starting anytime on or before cohort entry start date.

14. Extra exclusions

Entry events having no procedure occurrences of ‘Missing codes’, starting anytime on or before cohort entry start date.

Cohort Exit

The person exits the cohort at the end of continuous observation.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

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: { “CONCEPT_ID” : 915611, “CONCEPT_NAME” : “Counseling visit to discuss need for lung cancer screening using low dose ct scan (ldct) (service is for eligibility determination and shared decision making)”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “G0296”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “HCPCS”, “CONCEPT_CLASS_ID” : “HCPCS” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2617376, “CONCEPT_NAME” : “Low dose ct scan (ldct) for lung cancer screening”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “G0297”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “HCPCS”, “CONCEPT_CLASS_ID” : “HCPCS” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } }, { “id” : 5, “name” : “[Lung Cancer JMR] CHEST XRAY”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 725069, “CONCEPT_NAME” : “Radiologic examination, chest; 2 views”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71046”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211361, “CONCEPT_NAME” : “Radiologic examination, chest, 2 views, frontal and lateral”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71020”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211362, “CONCEPT_NAME” : “Radiologic examination, chest, 2 views, frontal and lateral; with apical lordotic procedure”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71021”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211364, “CONCEPT_NAME” : “Radiologic examination, chest, 2 views, frontal and lateral; with fluoroscopy”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71023”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211363, “CONCEPT_NAME” : “Radiologic examination, chest, 2 views, frontal and lateral; with oblique projections”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71022”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 724942, “CONCEPT_NAME” : “Radiologic examination, chest; 3 views”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71047”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 724943, “CONCEPT_NAME” : “Radiologic examination, chest; 4 or more views”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71048”, “DOMAIN_ID” : “Procedure”, 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“includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 725068, “CONCEPT_NAME” : “Radiologic examination, chest; single view”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71045”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211359, “CONCEPT_NAME” : “Radiologic examination, chest; single view, frontal”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71010”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211367, “CONCEPT_NAME” : “Radiologic examination, chest, special views (eg, lateral decubitus, Bucky studies)”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71035”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211360, “CONCEPT_NAME” : “Radiologic examination, chest; stereo, frontal”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71015”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2006694, “CONCEPT_NAME” : “Other soft tissue x-ray of chest wall”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “87.39”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “ICD9Proc”, “CONCEPT_CLASS_ID” : “4-dig billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4244393, “CONCEPT_NAME” : “Soft tissue X-ray of chest wall”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “38336006”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Procedure” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false } ] } }, { “id” : 6, “name” : “[Lung Cancer JMR] CHEST CT SCANS”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 2211379, “CONCEPT_NAME” : “Computed tomography, thorax; with contrast material(s)”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71260”, “DOMAIN_ID” : “Procedure”, 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“includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2894418, “CONCEPT_NAME” : “Imaging @ Respiratory System @ Computerized Tomography (CT Scan) @ Lungs, Bilateral”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “BB24”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “ICD10PCS”, “CONCEPT_CLASS_ID” : “ICD10PCS Hierarchy” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2814373, “CONCEPT_NAME” : “Imaging @ Respiratory System @ Computerized Tomography (CT Scan) @ Trachea/Airways”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “BB2F”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “ICD10PCS”, “CONCEPT_CLASS_ID” : “ICD10PCS Hierarchy” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2832534, “CONCEPT_NAME” : “Imaging @ Respiratory System @ Computerized Tomography (CT Scan) @ Tracheobronchial Tree, Left”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “BB28”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “ICD10PCS”, “CONCEPT_CLASS_ID” : “ICD10PCS Hierarchy” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2847056, “CONCEPT_NAME” : “Imaging @ Respiratory System @ Computerized Tomography (CT Scan) @ Tracheobronchial Tree, Right”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “BB27”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “ICD10PCS”, “CONCEPT_CLASS_ID” : “ICD10PCS Hierarchy” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2860312, “CONCEPT_NAME” : “Imaging @ Respiratory System @ Computerized Tomography (CT Scan) @ Tracheobronchial Trees, Bilateral”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “BB29”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “ICD10PCS”, “CONCEPT_CLASS_ID” : “ICD10PCS Hierarchy” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4327032, “CONCEPT_NAME” : “CT of thorax with contrast”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “75385009”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Procedure” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false } ] } }, { “id” : 7, “name” : “[Lung Cancer JMR] screen diagnosis”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 4152045, “CONCEPT_NAME” : “Screening for malignant neoplasm of respiratory tract”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “268546004”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Procedure” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } }, { “id” : 8, “name” : “[Lung Cancer JMR] abnormal image”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 437677, “CONCEPT_NAME” : “Abnormal findings on diagnostic imaging of lung”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “274533004”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4142875, “CONCEPT_NAME” : “Solitary nodule of lung”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “427359005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4168694, “CONCEPT_NAME” : “Lung field abnormal”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “274710003”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false } ] } }, { “id” : 9, “name” : “[Lung Cancer JMR] MRI for chest”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 2211385, “CONCEPT_NAME” : “Magnetic resonance angiography, chest (excluding myocardium), with or without contrast material(s)”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71555”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211382, “CONCEPT_NAME” : “Magnetic resonance (eg, proton) imaging, chest (eg, for evaluation of hilar and mediastinal lymphadenopathy); without contrast material(s)”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71550”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2211384, “CONCEPT_NAME” : “Magnetic resonance (eg, proton) imaging, chest (eg, for evaluation of hilar and mediastinal lymphadenopathy); without contrast material(s), followed by contrast material(s) and further sequences”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “71552”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4267450, “CONCEPT_NAME” : “MRI of chest and myocardium”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “62658002”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Procedure” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false } ] } }, { “id” : 10, “name” : “[Lung Cancer JMR] INTERESTING CPT CODE TO WATCH FOR”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 2101740, “CONCEPT_NAME” : “Computer-aided detection (CAD) (computer algorithm analysis of digital image data for lesion detection) with further physician review for interpretation and report, with or without digitization of film radiographic images, chest radiograph(s), performed c”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “0174T”, “DOMAIN_ID” : “Procedure”, “VOCABULARY_ID” : “CPT4”, “CONCEPT_CLASS_ID” : “CPT4” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 2101743, “CONCEPT_NAME” : “Computer-aided detection (CAD) (computer algorithm analysis of digital image data for lesion detection) with further physician review for interpretation and report, with or without digitization of film radiographic images, chest radiograph(s), performed r”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, 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“Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.799”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595513, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of left upper eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1991”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45600497, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of left upper limb, including shoulder”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.699”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45542601, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of lip”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.09”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1567527, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of lower limb, including hip”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.79”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45542603, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of nose”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.391”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45581214, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of other and unspecified parts of face”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.39”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45537812, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of other part of trunk”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.599”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45547497, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of other parts of face”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.399”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45547496, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of right ear and external auricular canal”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.292”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45561800, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of right eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.192”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595512, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of right lower eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1922”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45571509, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of right lower limb, including hip”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.792”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595511, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of right upper eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1921”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45561803, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of right upper limb, including shoulder”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.692”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45566586, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of scalp and neck”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.49”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45595656, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of trunk”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.59”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45556979, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of unspecified ear and external auricular canal”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.291”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45605272, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of unspecified eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.191”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45561804, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of unspecified lower limb, including hip”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.791”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45600495, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of unspecified parts of face”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.390”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45576314, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of unspecified upper limb, including shoulder”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.691”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1567525, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin of upper limb, including shoulder”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.69”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45537813, “CONCEPT_NAME” : “Other specified malignant neoplasm of skin, unspecified”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.99”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595503, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.13”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595508, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of left eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.139”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595510, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of left lower eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1392”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595509, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of left upper eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1391”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595505, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of right eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.132”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595507, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of right lower eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1322”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595506, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of right upper eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1321”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595504, “CONCEPT_NAME” : “Sebaceous cell carcinoma of skin of unspecified eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.131”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45586002, “CONCEPT_NAME” : “Squamous cell carcinoma of anal skin”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.520”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45600501, “CONCEPT_NAME” : “Squamous cell carcinoma of overlapping sites of skin”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.82”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4111921, “CONCEPT_NAME” : “Squamous cell carcinoma of skin”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “254651007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45600494, “CONCEPT_NAME” : “Squamous cell carcinoma of skin of nose”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.321”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45547498, “CONCEPT_NAME” : “Unspecified malignant neoplasm of anal skin”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.500”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45566590, “CONCEPT_NAME” : “Unspecified malignant neoplasm of overlapping sites of skin”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.80”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45586001, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of breast”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.501”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45556977, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of ear and external auricular canal”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.20”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45547493, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.10”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “5-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45542602, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of left ear and external auricular canal”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.209”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45600489, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of left eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.109”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char nonbill code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 1595494, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of left lower eyelid, including canthus”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.1092”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “7-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45571507, “CONCEPT_NAME” : “Unspecified malignant neoplasm of skin of left lower limb, including hip”, “STANDARD_CONCEPT” : “N”, “STANDARD_CONCEPT_CAPTION” : “Non-Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “C44.709”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “ICD10CM”, “CONCEPT_CLASS_ID” : “6-char billing code” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” 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“Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 11, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “Observation” : { “CodesetId” : 11, “ObservationTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior Biopsy Bronchoscopy”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 12, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior Add on procedures - biopsy”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “Measurement” : { “CodesetId” : 13, “MeasurementTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 13, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior Biopsy TTNA”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 14, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior Thoracic Surgery”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 15, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “Observation” : { “CodesetId” : 15, “ObservationTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior radiation”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “DeviceExposure” : { “CodesetId” : 17, “DeviceTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “DrugEra” : { “CodesetId” : 17 } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 17, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “Measurement” : { “CodesetId” : 17, “MeasurementTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior biopsy surgery”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 18, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “No prior ablation”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 23, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : “Extra exclusions”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 24, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } } ], “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 0 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 1 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (9202)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (9202))

) I ) C UNION ALL SELECT 4 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (915611,2617376)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (915611,2617376))

) I ) C UNION ALL SELECT 5 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (725069,2211361,2211362,2211364,2211363,724942,724943,2211365,2211366,725068,2211359,2211367,2211360,2006694,4244393)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (725069,2211361,2211362,2211364,2211363,724942,724943,2211365,2211366,725068,2211359,2211367,2211360))

) I ) C UNION ALL SELECT 6 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2211379,2211378,2211380,2894418,2814373,2832534,2847056,2860312,4327032)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (2211379,2211378,2211380,2894418,2814373,2832534,2847056,2860312))

) I ) C UNION ALL SELECT 7 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4152045)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4152045))

) I ) C UNION ALL SELECT 8 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (437677,4142875,4168694)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (437677,4142875))

) I ) C UNION ALL SELECT 9 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2211385,2211382,2211384,4267450)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (2211385,2211382,2211384))

) I ) C UNION ALL SELECT 10 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2101740,2101743)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (2101740,2101743))

) I ) C UNION ALL SELECT 11 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2211379,2211378,2211380,2212053,2212054,2212055,2212056,2212057,2212058,4305790,4327032,2617337,2617304,44782059)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (2211379,2211378,2211380,2212053,2212054,2212055,2212056,2212057,2212058))

) I ) C UNION ALL SELECT 12 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2106584,2106586,2106587,2106585,40756894,2106582,40757084,42627977,42628055,2106604,2106611,2106602,2106588,2106603,2106589,42627932,2106609,2106608,2831491,2742588,2742603,2742618,2742831,2742846,2742861,2742876,2743092,2743107,2743122,2743137,2743152,2743359,2743374,2743389,2743404,2743606,2743621,2743636,43016538,43016567,2743878,2743888,2743898,2743908,2743918,2744124,2744134,2744144,2744154,2744164,2744174,2744375,2744385,2744395,2744405,2744415,2744425,2744435,2744638,43016623,43016625,43016684,43016686,43016688,43016690,43016692,43016694,43016696,43016698,43016700,43016702,43016704,43016706,43016708,43016710,43016712,43016714,43016716,43016718,43016720)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (2106582))

) I ) C UNION ALL SELECT 14 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2106744,2106742,927071,927070,927069,927068,927073,927072,927067,927066,927065,2101870,2001403,4167261,2743872,2743882,2743892,2743902,2743912,2744118,2744128,2744138,2744148,2744158,2744168,2744178,2744379,2744389,2744399,2744409,2744419,2744429,2744632,2744642,2744648,2742579,2742594,2722708,2742624,2742837,2742852,2742867,2742882,2743098,2743113,2743128,2743143,2743350,2743365,2743380,2743395,2743597,2743612,2743627,2743642,2743651)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (2001403,4167261))

) I ) C UNION ALL SELECT 15 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2106762,2106751,2106764,42742515,2106830,42742517,42742510,4328240,2001340,2744450,2744451,2744446,2744447,2744444,2744445,2744442,2744443,2744440,2744441,2106765,2106748,2106750,2106749,42742518,4100718,4172438,2744456,2744457,2106767,42742513,42742514,2106823,42742286,42742511,42742512,42742505,42742506,42742508,42742509,2001333,2001334,40485447,2744438,2744635,2744639,2744408,2744412,2744416,2744428,2744432,2744436,2744388,2744392,2744396,2744378,2744382,2744386,2744418,2744422,2744426,2744177,2744181,2744376,2744167,2744171,2744175,2106763,2106765,42742516,2001336,4070880,2744398,2744402,2744406,2744448,2744449,2002329,4100937,2738153,2740664,2740665,4251336,2763265,2763271,2724110,2724194,2108485,42742521,2002329,4100937,2738153,2740664,2740665,2100843,2107476,2106870,2763264,2763270,2744437,2724109,2744407,2744427,2744387,2744397,2744399,2744405,2744377,2744417,2744176,2744166,2738152,4339613,4138959,2107478,4176147,4060079,4070879,4337606,4000882,4323902,2001345,4231736,4337608,2106766,42732582,42732581,42732580,42742519)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4328240,2001340,4100718))

) I ) C UNION ALL SELECT 16 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (261687)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (261687))

) I ) C UNION ALL SELECT 17 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2211837,2211839,46257523,46257522,46257423,2211852,46257457,2211875,2211874,2211887,2211886,2211888,2211889,2211890,2211891,46257688,46257736,2211840,2211897,2211894,2211893,2211892,42742550,42742549,42742551,40756993,2211885,2211884,2211883,2211882,2211877,2211867,2211863,2211859,2211870,2211855,2211854,2211858,2211876,42628030,42628064,42628642,42628483,42628029,44816358,2211848,2211853,2211844,2211880,2211856,2211879,2211878,2211906,2211905,46257422,46257728,2211871,2211836,2211834,2211833,2211832,2211831,2211851,2211850,2211849,2211907,2211857,2211838,2211881,45890648,2211803,42628035,42628582,2617415,2617416,45890647,45890649,45890641,45890642,45890640,45890639,45890645,45890646,45890644,45890643,45890637,45890638,45890636,45890633,2211859,2110553,2106610,40757145,2110100,40757107,40756930,40756828,2110048,2108627,2110050,2102718,2102717,2102716,725030,2110551,2110549,2110552,2110550,2110047,2615953,953300,2212071,2212066,2212075,2721108,40217350,40861704,43526934,43526937,44966628,2211847,2211846,2211845,3033361,3047342,3035898,3047799,3028328,3046507,3033437,3032574,3049561,3047810,927071,927070,2101759,40492764,2211896,2211895,2211865,2211866,2211864,2211869,2211868,2211861,2211862,2211860,42740104,2211440,2211843,2211842,2211841))

) I ) C UNION ALL SELECT 18 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2106789,2106804,2106802,42742286,42742511,42742512,42742507,42742505,42742506,2743624,2743630,2742591,2742597,43016570,43016576,2743110,2743116,2743392,2743398,2743609,2743615,2742864,2742870,2743648,2743654,2742879,2742885,2743362,2743368,2743095,2743101,2743377,2743383,2742849,2742855,2743347,2743353,2743407,2743600,2742606,2742612,2742834,2742840,2743140,2743146,2743639,2743645,2742621,2742627,2743125,2743131,2742576,2742582,2722710,2743870,2743874,2743880,2743884,2743894,2743890,2743900,2743904,2743914,2743910,2744120,2743920,2744130,2744126,2744140,2744136,2744150,2744146,2744160,2744156,2744170,2744166,2744180,2744176,2744381,2744377,2744391,2744387,2744401,2744397,2744411,2744407,2744421,2744417,2744431,2744427,2744634,2744437,2744644,2744640,2744650,2744646,43016645,43016627,43016683,43016685,43016687,43016689,43016691,43016693,43016695,43016697,43016699,43016701,43016703,43016705,43016707,43016709,43016711,43016713,43016715,43016717,43016719,2745154,2745158,2745164,2745160)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (42742505))

) I ) C UNION ALL SELECT 19 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (43533090,1594187,1397599,44818466,1344905,1315942,1325363,1350504,1319193,1378382,1314924,35605522,1343346,1397141,1594034,45775965,1304919,35604657,1747484,1747485,4098985,2721080)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (43533090,1594187,1397599,44818466,1344905,1315942,1325363,1350504,1319193,1378382,1314924,35605522,1343346,1397141,1594034,45775965,1304919,35604657))

) I ) C UNION ALL SELECT 20 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (36617886,4157333,4128888,4311499,44820369,45571395,2617376,2617376,44822914,2742877,2742876,2742619,2742618,43527945,2744892,2744679,256576,4187205,42628577,35206630,45556860,2744134,2743898,35225338,45890780,2741803,43016696,43016688,4171431,4314156,2741823,2742349,2742348,2742309,2742115,2744135,2743899,4180109,4201621,44786488,45890784,45890782,4308784,45890781,2106770,2106769,4311452,2744499,2744475,2743891,2744678,4181342,2743724,2743895,2745452,37110093,4080382,45890783,2743940,2743924,2742875,2742617,2744127,2743944,2742382,4314832,2742382,2743922,4038238,2742609,4334322,138641,443287,254830,43021270,35206100,45600357,44834216,4187206,44836599,45552121,4178968,4181339,43021270,4237016,4180910,46273418,2106769,4180788,40492021,4094720,43530658,43530658,1567471,46273372,46273372,40490009)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (36617886,4157333,4128888,4311499))

) I ) C UNION ALL SELECT 21 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4187205)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4187205))

) I ) C UNION ALL SELECT 22 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4155297,443392)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4155297,443392))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4112752,4111921)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4112752,4111921))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 23 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (45887512,725036,2106908,40664632,40664607,953297)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (45887512,725036,2106908,40664632,40664607,953297))

) I ) C UNION ALL SELECT 24 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (2211801,2211798,2211804,2211783,2212078,2211835,2211633,44816403,2779543,2780055,2777820,2777823,2108499,2108495,2108496,2108498,2108485,2106804,2106803,2106829,4022907,4022907,4128302,2106606,2106605,2106610,2106591,2106607,2106622,2106590,2106583,2001353,4119421,2001353,4311817,4167261,4119737,4085734))

) I ) C UNION ALL SELECT 25 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (44828738,44829809,44820611,44824027,44829807,44828737,44819432,44825203,44829808,44830980,44833298,44825202,44820608,44835675,44836835,44822882,44832126,44836836,44830979,44821729,44824028,44830982,44822883,44819429,44832127,44833296,44820609,44821727,44826404,44826403,44827560,44821730,44819433))

) I ) C UNION ALL SELECT 26 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (45600500,4112752,45561802,4155297,443392,35206206,1567515,1567518,1567516,35206204,1567526,1567520,35206205,1567522,1567524,35206207,45537811,45542607,45566588,1567519,1567517,45571504,45585996,1595514,45547502,1595513,45600497,45542601,1567527,45542603,45581214,45537812,45547497,45547496,45561800,1595512,45571509,1595511,45561803,45566586,45595656,45556979,45605272,45561804,45600495,45576314,1567525,45537813,1595503,1595508,1595510,1595509,1595505,1595507,1595506,1595504,45586002,45600501,4111921,45600494,45547498,45566590,45586001,45556977,45547493,45542602,45600489,1595494,45571507,1595493,45571506,45542600,45590900,45595654,45556980,45556981,45537808,45556978,45585995,1595492,45586006,1595491,45595657,45532907,1567523,45581213,45585994,45586005,45590895,45547499,45586003,45542608))

) I ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Visit Occurrence Criteria select C.person_id, C.visit_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select vo.person_id,vo.visit_occurrence_id,vo.visit_concept_id,vo.visit_start_date as start_date, vo.visit_end_date as end_date FROM @cdm_database_schema.VISIT_OCCURRENCE vo JOIN #Codesets cs on (vo.visit_concept_id = cs.concept_id and cs.codeset_id = 1) ) C JOIN @cdm_database_schema.PERSON P on C.person_id = P.person_id WHERE (C.start_date >= DATEFROMPARTS(2017, 1, 1) and C.start_date <= DATEFROMPARTS(2017, 12, 31)) AND (YEAR(C.start_date) - P.year_of_birth >= 45 and YEAR(C.start_date) - P.year_of_birth <= 65) – End Visit Occurrence Criteria

) E JOIN @cdm_database_schema.observation_period OP on E.person_id = OP.person_id and E.start_date >= OP.observation_period_start_date and E.start_date <= op.observation_period_end_date WHERE DATEADD(day,365,OP.OBSERVATION_PERIOD_START_DATE) <= E.START_DATE AND DATEADD(day,0,E.START_DATE) <= OP.OBSERVATION_PERIOD_END_DATE ) P WHERE P.ordinal = 1 – End Primary Events ) pe

) QE

;

— Inclusion Rule Inserts

select 0 as inclusion_rule_id, person_id, event_id INTO #Inclusion_0 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 20) ) C

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 21) ) C

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 20) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 3 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 20) ) C

– End Measurement Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 4 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 20) ) C

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 5 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id AND AC.event_id = pe.event_id ) Results ;

select 1 as inclusion_rule_id, person_id, event_id INTO #Inclusion_1 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( select PE.person_id, PE.event_id, PE.start_date, PE.end_date, PE.visit_occurrence_id, PE.sort_date FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Condition Occurrence Criteria

) PE JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) JOIN #Codesets cns on (co.condition_source_concept_id = cns.concept_id and cns.codeset_id = 26) ) C

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= DATEADD(day,0,P.START_DATE) AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 22) JOIN #Codesets cns on (co.condition_source_concept_id = cns.concept_id and cns.codeset_id = 25) ) C

– End Condition Occurrence Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 2 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id and AC.event_id = pe.event_id

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( select PE.person_id, PE.event_id, PE.start_date, PE.end_date, PE.visit_occurrence_id, PE.sort_date FROM ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Observation Criteria

) PE JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Observation Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Observation Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Observation Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) JOIN #Codesets cns on (o.observation_source_concept_id = cns.concept_id and cns.codeset_id = 26) ) C

– End Observation Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Observation Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) ) C

– End Observation Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 22) JOIN #Codesets cns on (o.observation_source_concept_id = cns.concept_id and cns.codeset_id = 25) ) C

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 2 as inclusion_rule_id, person_id, event_id INTO #Inclusion_2 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 19) ) C

– End Drug Exposure Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Device Exposure Criteria select C.person_id, C.device_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select de.person_id,de.device_exposure_id,de.device_concept_id,de.visit_occurrence_id,de.quantity,de.device_exposure_start_date as start_date, COALESCE(de.device_exposure_end_date, DATEADD(day,1,de.device_exposure_start_date)) as end_date FROM @cdm_database_schema.DEVICE_EXPOSURE de JOIN #Codesets cs on (de.device_concept_id = cs.concept_id and cs.codeset_id = 19) ) C

– End Device Exposure Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 3 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id AND AC.event_id = pe.event_id ) Results ;

select 3 as inclusion_rule_id, person_id, event_id INTO #Inclusion_3 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 4 as inclusion_rule_id, person_id, event_id INTO #Inclusion_4 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 4) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 5) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 3 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 7) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 4 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 8) ) C

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 5 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 9) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 6 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 10) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 7 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id AND AC.event_id = pe.event_id ) Results ;

select 5 as inclusion_rule_id, person_id, event_id INTO #Inclusion_5 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 11) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 6 as inclusion_rule_id, person_id, event_id INTO #Inclusion_6 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 12) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 7 as inclusion_rule_id, person_id, event_id INTO #Inclusion_7 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Measurement Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 8 as inclusion_rule_id, person_id, event_id INTO #Inclusion_8 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 9 as inclusion_rule_id, person_id, event_id INTO #Inclusion_9 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 15) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 10 as inclusion_rule_id, person_id, event_id INTO #Inclusion_10 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Device Exposure Criteria select C.person_id, C.device_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select de.person_id,de.device_exposure_id,de.device_concept_id,de.visit_occurrence_id,de.quantity,de.device_exposure_start_date as start_date, COALESCE(de.device_exposure_end_date, DATEADD(day,1,de.device_exposure_start_date)) as end_date FROM @cdm_database_schema.DEVICE_EXPOSURE de JOIN #Codesets cs on (de.device_concept_id = cs.concept_id and cs.codeset_id = 17) ) C

– End Device Exposure Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Drug Era Criteria select C.person_id, C.drug_era_id as event_id, C.start_date, C.end_date, CAST(NULL as bigint) as visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_era_id,de.drug_concept_id,de.drug_exposure_count,de.gap_days,de.drug_era_start_date as start_date, de.drug_era_end_date as end_date FROM @cdm_database_schema.DRUG_ERA de where de.drug_concept_id in (SELECT concept_id from #Codesets where codeset_id = 17) ) C

– End Drug Era Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

– End Measurement Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 4 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id AND AC.event_id = pe.event_id ) Results ;

select 11 as inclusion_rule_id, person_id, event_id INTO #Inclusion_11 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 18) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 12 as inclusion_rule_id, person_id, event_id INTO #Inclusion_12 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 23) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

select 13 as inclusion_rule_id, person_id, event_id INTO #Inclusion_13 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Procedure Occurrence Criteria select C.person_id, C.procedure_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select po.person_id,po.procedure_occurrence_id,po.procedure_concept_id,po.visit_occurrence_id,po.quantity,po.procedure_date as start_date, DATEADD(day,1,po.procedure_date) as end_date FROM @cdm_database_schema.PROCEDURE_OCCURRENCE po JOIN #Codesets cs on (po.procedure_concept_id = cs.concept_id and cs.codeset_id = 24) ) C

– End Procedure Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

SELECT inclusion_rule_id, person_id, event_id INTO #inclusion_events FROM (select inclusion_rule_id, person_id, event_id from #Inclusion_0 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_1 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_2 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_3 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_4 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_5 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_6 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_7 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_8 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_9 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_10 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_11 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_12 UNION ALL select inclusion_rule_id, person_id, event_id from #Inclusion_13) I; TRUNCATE TABLE #Inclusion_0; DROP TABLE #Inclusion_0;

TRUNCATE TABLE #Inclusion_1; DROP TABLE #Inclusion_1;

TRUNCATE TABLE #Inclusion_2; DROP TABLE #Inclusion_2;

TRUNCATE TABLE #Inclusion_3; DROP TABLE #Inclusion_3;

TRUNCATE TABLE #Inclusion_4; DROP TABLE #Inclusion_4;

TRUNCATE TABLE #Inclusion_5; DROP TABLE #Inclusion_5;

TRUNCATE TABLE #Inclusion_6; DROP TABLE #Inclusion_6;

TRUNCATE TABLE #Inclusion_7; DROP TABLE #Inclusion_7;

TRUNCATE TABLE #Inclusion_8; DROP TABLE #Inclusion_8;

TRUNCATE TABLE #Inclusion_9; DROP TABLE #Inclusion_9;

TRUNCATE TABLE #Inclusion_10; DROP TABLE #Inclusion_10;

TRUNCATE TABLE #Inclusion_11; DROP TABLE #Inclusion_11;

TRUNCATE TABLE #Inclusion_12; DROP TABLE #Inclusion_12;

TRUNCATE TABLE #Inclusion_13; DROP TABLE #Inclusion_13;

– the matching group with all bits set ( POWER(2,# of inclusion rules) - 1 = inclusion_rule_mask WHERE (MG.inclusion_rule_mask = POWER(cast(2 as bigint),14)-1)

) Results WHERE Results.ordinal = 1 ;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

[PP target] All events COVID-19, positive test or dx with NO cooccurring negative test, 180d washout

Cohort Entry Events

People may enter the cohort when observing any of the following:

measurements of ‘SARS-CoV-2 test’, starting after December 1, 2019; with value as concept: “detected”, “detected”, “positive”, “positive”, “present” or “present”.
condition occurrences of ‘COVID-19’, starting after December 1, 2019; having no measurements of ‘SARS-CoV-2 test’, starting between 0 days before and 3 days after ‘COVID-19’ start date; with value as concept: “negative”, “not detected”, “not detected in pooled specimen”, “absent”, “negative”, “not detected”, “absent” or “n”.

Inclusion Criteria

1. age >= 18

Entry events with the following event criteria: who are >= 18 years old.

2. has >= 365d of prior observation

Entry events having at least 1 observation period, starting anytime up to 365 days before cohort entry start date and ending between 0 days before and all days after cohort entry start date.

3. no symptoms or pneumonia in the last 60d

Entry events with all of the following criteria:

having no condition occurrences of ‘[Covid v1] Pneumonia’, starting in the 60 days prior to cohort entry start date.
having no condition occurrences of ‘[OHDSI Cov19] Cough’, starting in the 60 days prior to cohort entry start date.
having no condition occurrences of ‘[Covid19 v1] Myalgia’, starting in the 60 days prior to cohort entry start date.
having no condition occurrences of ‘[Covid v1] Malaise or Fatigue or (Malaise and Fatigue)’, starting in the 60 days prior to cohort entry start date.
having no condition occurrences of ‘[COVID V1] Shortness of breath (dyspnea)’, starting in the 60 days prior to cohort entry start date.
having no condition occurrences of ‘[COVID19 v1] Fever (38.0C or higher) pre-coordinated measurements and conditions’, starting in the 60 days prior to cohort entry start date.
having no measurements of ‘[COVID19 v1] Fever (38.0C or higher) pre-coordinated measurements and conditions’, starting in the 60 days prior to cohort entry start date.
having no measurements of ‘[COVID v1] Fever (38.0C or higher) measurement and observation’, starting in the 60 days prior to cohort entry start date; numeric value between 38 and 42; unit: “degree celsius”.
having no observations of ‘[COVID v1] Fever (38.0C or higher) measurement and observation’, starting in the 60 days prior to cohort entry start date; numeric value between 38 and 42; unit: “degree celsius”.
having no measurements of ‘[COVID v1] Fever (38.0C or higher) measurement and observation’, starting in the 60 days prior to cohort entry start date; numeric value between 100.4 and 120; unit: “degree fahrenheit”.
having no observations of ‘[COVID v1] Fever (38.0C or higher) measurement and observation’, starting in the 60 days prior to cohort entry start date; numeric value between 100.4 and 120; unit: “degree fahrenheit”.

4. no influenza in the last 60d

Entry events with all of the following criteria:

having no condition occurrences of ‘[COVID19 v1] Influenza (including complications) - Conditions’, starting in the 60 days prior to cohort entry start date.
having no measurements of ‘[COVID19 v1] Influenza (pre-coordinated Positive Measurements’, starting in the 60 days prior to cohort entry start date.
having no measurements of ‘[COVID19 v1] Influenza testing (excluding Ab testing)’, starting in the 60 days prior to cohort entry start date; with value as concept: “detected”, “detected”, “positive”, “positive”, “present” or “present”.
having no observations of ‘[COVID19 v1] Influenza testing (excluding Ab testing)’, starting in the 60 days prior to cohort entry start date; with value as concept: “detected”, “detected”, “positive”, “positive”, “present” or “present”.

5. no Covid diagnosis or test in the last 60d

Entry events with all of the following criteria:

having no condition occurrences of ‘COVID-19’, starting in the 60 days prior to cohort entry start date.
having no observations of ‘SARS-CoV-2 test’, starting in the 60 days prior to cohort entry start date; with value as concept: “detected”, “detected”, “positive”, “positive”, “present” or “present”.
having no measurements of ‘SARS-CoV-2 test’, starting in the 60 days prior to cohort entry start date; with value as concept: “detected”, “detected”, “positive”, “positive”, “present” or “present”.

Cohort Exit

The cohort end date will be offset from index event’s start date plus 3 days.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 180 days of each other.

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“STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “52101004”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : null }, { “CONCEPT_ID” : 45879438, “CONCEPT_NAME” : “Present”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “LA9633-4”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “LOINC”, “CONCEPT_CLASS_ID” : null } ] } }, “StartWindow” : { “Start” : { “Days” : 60, “Coeff” : -1 }, “End” : { “Days” : 1, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “Measurement” : { “CodesetId” : 7, “MeasurementTypeExclude” : false, “ValueAsConcept” : [ { “CONCEPT_ID” : 4126681, “CONCEPT_NAME” : “Detected”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “260373001”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : null }, { “CONCEPT_ID” : 45877985, “CONCEPT_NAME” : “Detected”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “LA11882-0”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “LOINC”, “CONCEPT_CLASS_ID” : null }, { “CONCEPT_ID” : 9191, “CONCEPT_NAME” : “Positive”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “10828004”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : null }, { “CONCEPT_ID” : 45884084, “CONCEPT_NAME” : “Positive”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “LA6576-8”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “LOINC”, “CONCEPT_CLASS_ID” : null }, { “CONCEPT_ID” : 4181412, “CONCEPT_NAME” : “Present”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “52101004”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : null }, { “CONCEPT_ID” : 45879438, “CONCEPT_NAME” : “Present”, “STANDARD_CONCEPT” : null, “STANDARD_CONCEPT_CAPTION” : “Unknown”, “INVALID_REASON” : null, “INVALID_REASON_CAPTION” : “Unknown”, “CONCEPT_CODE” : “LA9633-4”, “DOMAIN_ID” : “Meas Value”, “VOCABULARY_ID” : “LOINC”, “CONCEPT_CLASS_ID” : null } ] } }, “StartWindow” : { “Start” : { “Days” : 60, “Coeff” : -1 }, “End” : { “Days” : 1, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } } ], “EndStrategy” : { “DateOffset” : { “DateField” : “StartDate”, “Offset” : 3 } }, “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 180 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 6 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (37311061,704996,704995,704999,704997)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (37311061,704996,704995,704999,704997))

) I ) C UNION ALL SELECT 7 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (756055,3966513,36032061,1617448,36033647,36033643,36033651,706158,706169,36661384,36661376,36032352,36031861,36031949)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (756055,3966513,36032061,1617448,36033647,36033643,36033651,706158,706169,36661384,36661376,36032352,36031861,36031949))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (37310258,21492988,37020635,21492989,37021252,37021152)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (37310258,21492988,37020635,21492989,37021252,37021152))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 8 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4050869,255848)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4050869,255848))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (45770911,4001167,4049965,36712839,252552)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (45770911,4001167,4049965,36712839,252552))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 9 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (254761,4089228)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (254761,4089228))

) I ) C UNION ALL SELECT 10 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (442752)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (442752))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (258828,4298555,195464,442315,4347181,442774,36713056,37118025,4316217,37312366,46284893)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (258828,4298555,195464,442315,4347181,442774,36713056,37118025,4316217,37312366,46284893))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 11 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4223659,4272240,1572255,439926,44829293,44823445,1572256)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4223659,4272240,1572255,439926,44829293,44823445,1572256))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4158491,37396808,4219363,4221911,37205051,37205052,45772721,4225027,40484614,4092860,4090207,44782753)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4158491,37396808,4219363,4221911,37205051,37205052,45772721,4225027,40484614,4092860,4090207,44782753))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 12 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4191650,312437)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4191650,312437))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4222908)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4222908))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 13 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (444413,437663,4141062,4152360)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (444413,437663,4141062,4152360))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4346179,4170869,4226022,37205085,4318555,37016869,443908,4093997,4347651,440285,4087628,4143214,4039793,37397178,40493465,4199309,44784428,44784427,44784429,44782483,43530646,4086668,3197956,4094003,43530637,37017455,4087629,4150518,4184347,4326408,4200980,4229442,4239624,4300533,4308214,4099900,4094000,4087017,438963,4243806)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4346179,4170869,4226022,37205085,4318555,37016869,443908,4093997,4347651,440285,4087628,4143214,4039793,37397178,40493465,4199309,44784428,44784427,44784429,44782483,43530646,4086668,3197956,4094003,43530637,37017455,4087629,4150518,4184347,4326408,4200980,4229442,4239624,4300533,4308214,4099900,4094000,4087017,438963,4243806))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 14 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (3025085,21490870,21490688,3020891,3025926,3025704,3017614,3011783,3004750,3008557,3007846,3016117,3006749,3016715,3018145,3015039,3009553,4329518,4174894,21490907,21490588,4212763,44809208,21490906,21490590,4039793,4077057,4039791,4151775,3006322,3022060,4265708,3025163)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (3025085,21490870,21490688,3020891,3025926,3025704,3017614,3011783,3004750,3008557,3007846,3016117,3006749,3016715,3018145,3015039,3009553,4329518,4174894,21490907,21490588,4212763,44809208,21490906,21490590,4039793,4077057,4039791,4151775,3006322,3022060,4265708,3025163))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4189949,4040476,4039792,4040104,4164378,4039796,4039795,4040106,4039794,4038778,45769775,4267945)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4189949,4040476,4039792,4040104,4164378,4039796,4039795,4040106,4039794,4038778,45769775,4267945))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 15 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4146943,46274061,4266367,42537960,4112824,4299935,46269706,763011)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4146943,46274061,4266367,42537960,4112824,4299935,46269706,763011))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4042202)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4042202))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 16 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (45757528,4262075)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (45757528,4262075))

) I ) C UNION ALL SELECT 17 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (44789502,37392948,37394408,36676235,3001703,3016424,3038149,3016676,3017256,3020370,2213094,2213181,2213063,2213062,40757077,40756898,4039357,37392223,44806470,37394297,4044987,4039358,37392224,44807860,37394300,4044988,37392761,40653953,40655680,40655681,40655682,40655683,40655684,40655685,40655686,37080282,40655687,40655688,40655689,40655690,4047171,40655691,40484560,3002988,3002646,3003682)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (44789502,37392948,37394408,36676235,3001703,3016424,3038149,3016676,3017256,3020370,2213094,2213181,2213063,2213062,40757077,40756898,4039357,37392223,44806470,37394297,4044987,4039358,37392224,44807860,37394300,4044988,37392761,40653953,40655680,40655681,40655682,40655683,40655684,40655685,40655686,37080282,40655687,40655688,40655689,40655690,4047171,40655691,40484560,3002988,3002646,3003682))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (37066972,3002696,3000619,3023674,3001047,3007341,37398130,4201049,37393224,44805899,45757528,37393225,4196405,44805900,4262075,40760327,37048815,37058506,37055728,37040765,37023170,37075082,37041511,37066453,37057346,37054344,37022661,37067997,37028300,37054453,37036578,37078464,37067504,37070652,37048012,37071077,37042025,37024679,37042070,37052164,37037245,37072518,37044556,37025175,37063376,37068553,37045806,37036252,37064420,37037941,37062169,37076139,37034233,37051887,37075960,37022372,37031117,37073627,37057853,37042870,37075259,37030627,37059249,37037961,37047321,37075847,37073492,37056311,37029363,37023424,37073273,37076384,37069805,37026917,37048913,37074405,37040736,37076803,37075491,37072743,40758391,42869813,40758149,3043198,4017924,37050279,3026510,3027889)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (37066972,3002696,3000619,3023674,3001047,3007341,37398130,4201049,37393224,44805899,45757528,37393225,4196405,44805900,4262075,40760327,37048815,37058506,37055728,37040765,37023170,37075082,37041511,37066453,37057346,37054344,37022661,37067997,37028300,37054453,37036578,37078464,37067504,37070652,37048012,37071077,37042025,37024679,37042070,37052164,37037245,37072518,37044556,37025175,37063376,37068553,37045806,37036252,37064420,37037941,37062169,37076139,37034233,37051887,37075960,37022372,37031117,37073627,37057853,37042870,37075259,37030627,37059249,37037961,37047321,37075847,37073492,37056311,37029363,37023424,37073273,37076384,37069805,37026917,37048913,37074405,37040736,37076803,37075491,37072743,40758391,42869813,40758149,3043198,4017924,37050279,3026510,3027889))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.value_as_concept_id,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 7) ) C

WHERE C.start_date > DATEFROMPARTS(2019, 12, 1) AND C.value_as_concept_id in (4126681,45877985,9191,45884084,4181412,45879438) – End Measurement Criteria

UNION ALL select PE.person_id, PE.event_id, PE.start_date, PE.end_date, PE.visit_occurrence_id, PE.sort_date FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 6) ) C

WHERE C.start_date > DATEFROMPARTS(2019, 12, 1) – End Condition Occurrence Criteria

WHERE C.start_date > DATEFROMPARTS(2019, 12, 1) – End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 6) ) C

WHERE C.start_date > DATEFROMPARTS(2019, 12, 1) – End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 6) ) C

WHERE C.start_date > DATEFROMPARTS(2019, 12, 1) – End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.value_as_concept_id,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 7) ) C

WHERE C.value_as_concept_id in (9189,9190,3661867,4132135,45878583,45880296,45884086,46237074) – End Measurement Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= DATEADD(day,0,P.START_DATE) AND A.START_DATE <= DATEADD(day,3,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) > 0 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id and AC.event_id = pe.event_id

– End Primary Events ) pe

) QE

;

— Inclusion Rule Inserts

select 0 as inclusion_rule_id, person_id, event_id INTO #Inclusion_0 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Demographic Criteria SELECT 0 as index_id, e.person_id, e.event_id FROM #qualified_events E JOIN @cdm_database_schema.PERSON P ON P.PERSON_ID = E.PERSON_ID WHERE YEAR(E.start_date) - P.year_of_birth >= 18 GROUP BY e.person_id, e.event_id – End Demographic Criteria

select 1 as inclusion_rule_id, person_id, event_id INTO #Inclusion_1 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

– End Observation Period Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,-365,P.START_DATE) AND A.END_DATE >= DATEADD(day,0,P.START_DATE) AND A.END_DATE <= P.OP_END_DATE ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

select 2 as inclusion_rule_id, person_id, event_id INTO #Inclusion_2 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= DATEADD(day,-60,P.START_DATE) AND A.START_DATE <= DATEADD(day,-1,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 9) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 10) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 3 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 11) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 4 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 12) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 5 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 6 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Measurement Criteria

UNION ALL – Begin Correlated Criteria select 7 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.unit_concept_id,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

WHERE (C.value_as_number >= 38.0000 and C.value_as_number <= 42.0000) AND C.unit_concept_id in (8653) – End Measurement Criteria

UNION ALL – Begin Correlated Criteria select 8 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.unit_concept_id,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

WHERE (C.value_as_number >= 38.0000 and C.value_as_number <= 42.0000) AND C.unit_concept_id in (8653) – End Observation Criteria

UNION ALL – Begin Correlated Criteria select 9 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.unit_concept_id,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

WHERE (C.value_as_number >= 100.4000 and C.value_as_number <= 120.0000) AND C.unit_concept_id in (9289) – End Measurement Criteria

UNION ALL – Begin Correlated Criteria select 10 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.unit_concept_id,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

WHERE (C.value_as_number >= 100.4000 and C.value_as_number <= 120.0000) AND C.unit_concept_id in (9289) – End Observation Criteria

) CQ on E.person_id = CQ.person_id and E.event_id = CQ.event_id GROUP BY E.person_id, E.event_id HAVING COUNT(index_id) = 11 ) G – End Criteria Group ) AC on AC.person_id = pe.person_id AND AC.event_id = pe.event_id ) Results ;

select 3 as inclusion_rule_id, person_id, event_id INTO #Inclusion_3 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 16) ) C

– End Measurement Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.value_as_concept_id,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 17) ) C

WHERE C.value_as_concept_id in (4126681,45877985,9191,45884084,4181412,45879438) – End Measurement Criteria

UNION ALL – Begin Correlated Criteria select 3 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.value_as_concept_id,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 17) ) C

WHERE C.value_as_concept_id in (4126681,45877985,9191,45884084,4181412,45879438) – End Observation Criteria

select 4 as inclusion_rule_id, person_id, event_id INTO #Inclusion_4 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.value_as_concept_id,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 7) ) C

WHERE C.value_as_concept_id in (4126681,45877985,9191,45884084,4181412,45879438) – End Observation Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Measurement Criteria select C.person_id, C.measurement_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select m.person_id,m.measurement_id,m.measurement_concept_id,m.visit_occurrence_id,m.value_as_number,m.range_high,m.range_low,m.value_as_concept_id,m.measurement_date as start_date, DATEADD(day,1,m.measurement_date) as end_date FROM @cdm_database_schema.MEASUREMENT m JOIN #Codesets cs on (m.measurement_concept_id = cs.concept_id and cs.codeset_id = 7) ) C

WHERE C.value_as_concept_id in (4126681,45877985,9191,45884084,4181412,45879438) – End Measurement Criteria

TRUNCATE TABLE #Inclusion_1; DROP TABLE #Inclusion_1;

TRUNCATE TABLE #Inclusion_2; DROP TABLE #Inclusion_2;

TRUNCATE TABLE #Inclusion_3; DROP TABLE #Inclusion_3;

TRUNCATE TABLE #Inclusion_4; DROP TABLE #Inclusion_4;

– the matching group with all bits set ( POWER(2,# of inclusion rules) - 1 = inclusion_rule_mask WHERE (MG.inclusion_rule_mask = POWER(cast(2 as bigint),5)-1)

) Results

;

– date offset strategy

select event_id, person_id, case when DATEADD(day,3,start_date) > op_end_date then op_end_date else DATEADD(day,3,start_date) end as end_date INTO #strategy_ends from #included_events;

– generate cohort periods into #final_cohort select person_id, start_date, end_date INTO #cohort_rows from ( – first_ends select F.person_id, F.start_date, F.end_date FROM ( select I.event_id, I.person_id, I.start_date, CE.end_date, row_number() over (partition by I.person_id, I.event_id order by CE.end_date) as ordinal from #included_events I join ( – cohort_ends – cohort exit dates – End Date Strategy SELECT event_id, person_id, end_date from #strategy_ends

) CE on I.event_id = CE.event_id and I.person_id = CE.person_id and CE.end_date >= I.start_date
) F
WHERE F.ordinal = 1

) FE;

select person_id, min(start_date) as start_date, DATEADD(day,-1 * 180, max(end_date)) as end_date into #final_cohort from ( select person_id, start_date, end_date, sum(is_start) over (partition by person_id order by start_date, is_start desc rows unbounded preceding) group_idx from ( select person_id, start_date, end_date, case when max(end_date) over (partition by person_id order by start_date rows between unbounded preceding and 1 preceding) >= start_date then 0 else 1 end is_start from ( select person_id, start_date, DATEADD(day,180,end_date) as end_date from #cohort_rows ) CR ) ST ) GR group by person_id, group_idx;

TRUNCATE TABLE #strategy_ends; DROP TABLE #strategy_ends;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

Outcome Cohorts

[PL] All events of Non-hemorrhagic Stroke in an inpatient setting, with a washout period of 365 days

Cohort Entry Events

People may enter the cohort when observing any of the following:

condition occurrences of ‘Cerebral infarction’.

Restrict entry events to having at least 1 visit occurrence of ‘Inpatient or Inpatient/ER visit’, starting anytime on or before cohort entry start date and ending between 0 days before and all days after cohort entry start date.

Inclusion Criteria

1. has no events in prior ‘clean window’ - 365 days

Entry events having no condition occurrences of ‘Cerebral infarction’, starting in the 365 days prior to cohort entry start date; allow events outside observation period; having at least 1 visit occurrence of ‘Inpatient or Inpatient/ER visit’, starting anytime on or before ‘Cerebral infarction’ start date and ending between 0 days before and all days after ‘Cerebral infarction’ start date.

Cohort Exit

The cohort end date will be offset from index event’s start date plus 1 day.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

{ “cdmVersionRange” : “>=5.0.0”, “PrimaryCriteria” : { “CriteriaList” : [ { “ConditionOccurrence” : { “CodesetId” : 3, “ConditionTypeExclude” : false } } ], “ObservationWindow” : { “PriorDays” : 0, “PostDays” : 0 }, “PrimaryCriteriaLimit” : { “Type” : “All” } }, “AdditionalCriteria” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “VisitOccurrence” : { “CodesetId” : 2, “VisitTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] }, “ConceptSets” : [ { “id” : 2, “name” : “Inpatient or Inpatient/ER visit”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 262, “CONCEPT_NAME” : “Emergency Room and Inpatient Visit”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “ERIP”, “DOMAIN_ID” : “Visit”, “VOCABULARY_ID” : “Visit”, “CONCEPT_CLASS_ID” : “Visit” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 9201, “CONCEPT_NAME” : “Inpatient Visit”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “IP”, “DOMAIN_ID” : “Visit”, “VOCABULARY_ID” : “Visit”, “CONCEPT_CLASS_ID” : “Visit” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } }, { “id” : 3, “name” : “Cerebral infarction”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 443454, “CONCEPT_NAME” : “Cerebral infarction”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “432504007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 40479572, “CONCEPT_NAME” : “Infarct of cerebrum due to iatrogenic cerebrovascular accident”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “441526008”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4046360, “CONCEPT_NAME” : “Lacunar infarction”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “230698000”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 372435, “CONCEPT_NAME” : “Periventricular leukomalacia”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “230769007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 377254, “CONCEPT_NAME” : “Multi-infarct dementia, uncomplicated”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “70936005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 379778, “CONCEPT_NAME” : “Multi-infarct dementia”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “56267009”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 443790, “CONCEPT_NAME” : “Multi-infarct dementia with delusions”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “25772007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 443864, “CONCEPT_NAME” : “Multi-infarct dementia with depression”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “14070001”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 444091, “CONCEPT_NAME” : “Multi-infarct dementia with delirium”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “10349009”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4046089, “CONCEPT_NAME” : “Vascular dementia of acute onset”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “230285003”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4046090, “CONCEPT_NAME” : “Mixed cortical and subcortical vascular dementia”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “230287006”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4129534, “CONCEPT_NAME” : “Pituitary apoplexy”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “237701005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : false, “includeMapped” : false } ] } } ], “QualifiedLimit” : { “Type” : “All” }, “ExpressionLimit” : { “Type” : “All” }, “InclusionRules” : [ { “name” : “has no events in prior ‘clean window’ - 365 days”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ConditionOccurrence” : { “CorrelatedCriteria” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “VisitOccurrence” : { “CodesetId” : 2, “VisitTypeExclude” : false } }, “StartWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] }, “CodesetId” : 3, “ConditionTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 365, “Coeff” : -1 }, “End” : { “Days” : 1, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } } ], “EndStrategy” : { “DateOffset” : { “DateField” : “StartDate”, “Offset” : 1 } }, “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 0 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 2 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (262,9201)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (262,9201))

) I ) C UNION ALL SELECT 3 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (443454)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (443454))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (40479572,4046360,372435,377254,379778,443790,443864,444091,4046089,4046090,4129534)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (40479572,4046360))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

– End Condition Occurrence Criteria

– End Primary Events ) pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

– End Condition Occurrence Criteria

– End Primary Events ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

– End Condition Occurrence Criteria

– End Primary Events ) P JOIN ( – Begin Visit Occurrence Criteria select C.person_id, C.visit_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select vo.person_id,vo.visit_occurrence_id,vo.visit_concept_id,vo.visit_start_date as start_date, vo.visit_end_date as end_date FROM @cdm_database_schema.VISIT_OCCURRENCE vo JOIN #Codesets cs on (vo.visit_concept_id = cs.concept_id and cs.codeset_id = 2) ) C

– End Visit Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) AND A.END_DATE >= DATEADD(day,0,P.START_DATE) AND A.END_DATE <= P.OP_END_DATE ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

) QE

;

— Inclusion Rule Inserts

select 0 as inclusion_rule_id, person_id, event_id INTO #Inclusion_0 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from #qualified_events p LEFT JOIN ( SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( select PE.person_id, PE.event_id, PE.start_date, PE.end_date, PE.visit_occurrence_id, PE.sort_date FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

– End Condition Occurrence Criteria

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

– End Visit Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= DATEADD(day,0,P.START_DATE) AND A.END_DATE >= DATEADD(day,0,P.START_DATE) AND A.END_DATE <= P.OP_END_DATE ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= DATEADD(day,-365,P.START_DATE) AND A.START_DATE <= DATEADD(day,-1,P.START_DATE) ) cc on p.person_id = cc.person_id and p.event_id = cc.event_id GROUP BY p.person_id, p.event_id HAVING COUNT(cc.event_id) = 0 – End Correlated Criteria

SELECT inclusion_rule_id, person_id, event_id INTO #inclusion_events FROM (select inclusion_rule_id, person_id, event_id from #Inclusion_0) I; TRUNCATE TABLE #Inclusion_0; DROP TABLE #Inclusion_0;

– the matching group with all bits set ( POWER(2,# of inclusion rules) - 1 = inclusion_rule_mask WHERE (MG.inclusion_rule_mask = POWER(cast(2 as bigint),1)-1)

) Results

;

– date offset strategy

select event_id, person_id, case when DATEADD(day,1,start_date) > op_end_date then op_end_date else DATEADD(day,1,start_date) end as end_date INTO #strategy_ends from #included_events;

– generate cohort periods into #final_cohort select person_id, start_date, end_date INTO #cohort_rows from ( – first_ends select F.person_id, F.start_date, F.end_date FROM ( select I.event_id, I.person_id, I.start_date, CE.end_date, row_number() over (partition by I.person_id, I.event_id order by CE.end_date) as ordinal from #included_events I join ( – cohort_ends – cohort exit dates – End Date Strategy SELECT event_id, person_id, end_date from #strategy_ends

) CE on I.event_id = CE.event_id and I.person_id = CE.person_id and CE.end_date >= I.start_date
) F
WHERE F.ordinal = 1

) FE;

TRUNCATE TABLE #strategy_ends; DROP TABLE #strategy_ends;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

Death event

Cohort Entry Events

People enter the cohort when observing any of the following:

death of any form.

Limit cohort entry events to the earliest event per person.

Cohort Exit

The person exits the cohort at the end of continuous observation.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

{ “cdmVersionRange” : “>=5.0.0”, “PrimaryCriteria” : { “CriteriaList” : [ { “Death” : { “DeathTypeExclude” : false } } ], “ObservationWindow” : { “PriorDays” : 0, “PostDays” : 0 }, “PrimaryCriteriaLimit” : { “Type” : “First” } }, “ConceptSets” : [], “QualifiedLimit” : { “Type” : “First” }, “ExpressionLimit” : { “Type” : “First” }, “InclusionRules” : [], “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 0 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Death Criteria select C.person_id, C.person_id as event_id, C.start_date, c.end_date, CAST(NULL as bigint) as visit_occurrence_id, C.start_date as sort_date from ( select d.person_id,d.cause_concept_id,d.death_date as start_date, DATEADD(day,1,d.death_date) as end_date FROM @cdm_database_schema.DEATH d

) C

– End Death Criteria

) QE

;

— Inclusion Rule Inserts

create table #inclusion_events (inclusion_rule_id bigint, person_id bigint, event_id bigint );

) Results WHERE Results.ordinal = 1 ;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

Lung Cancer Prediction O 2 - 2 primary lung cancer diagnosis

Cohort Entry Events

People may enter the cohort when observing any of the following:

condition occurrences of ‘Primary Lung Cancer’.

Inclusion Criteria

1. Another code within 60 days

Entry events having at least 1 condition occurrence of ‘Primary Lung Cancer’, starting between 1 days after and 60 days after cohort entry start date.

Limit qualifying entry events to the earliest event per person.

Cohort Exit

The person exits the cohort at the end of continuous observation.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 0 days of each other.

{ “cdmVersionRange” : “>=5.0.0”, “PrimaryCriteria” : { “CriteriaList” : [ { “ConditionOccurrence” : { “CodesetId” : 2, “ConditionTypeExclude” : false } } ], “ObservationWindow” : { “PriorDays” : 0, “PostDays” : 0 }, “PrimaryCriteriaLimit” : { “Type” : “All” } }, “ConceptSets” : [ { “id” : 2, “name” : “Primary Lung Cancer”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 36617886, “CONCEPT_NAME” : “Lung cancer metastatic”, “STANDARD_CONCEPT” : “C”, “STANDARD_CONCEPT_CAPTION” : “Classification”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “10050017”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “MedDRA”, “CONCEPT_CLASS_ID” : “PT” }, “isExcluded” : true, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4157333, “CONCEPT_NAME” : “Malignant neoplasm of main bronchus”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “372065009”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4128888, “CONCEPT_NAME” : “Neoplasm of lung”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “126713003”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 254591, “CONCEPT_NAME” : “Secondary malignant neoplasm of lung”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “94391008”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4248073, “CONCEPT_NAME” : “Secondary malignant neoplasm of main bronchus”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “94399005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 443388, “CONCEPT_NAME” : “Malignant tumor of lung”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “363358000”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4242353, “CONCEPT_NAME” : “Benign neoplasm of lung”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “92196005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Clinical Finding” }, “isExcluded” : true, “includeDescendants” : true, “includeMapped” : false } ] } } ], “QualifiedLimit” : { “Type” : “First” }, “ExpressionLimit” : { “Type” : “First” }, “InclusionRules” : [ { “name” : “Another code within 60 days”, “expression” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 2, “ConditionTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 1, “Coeff” : 1 }, “End” : { “Days” : 60, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } } ], “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 0 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 2 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4157333,4128888,443388)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4157333,4128888,443388))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (36617886,254591,4248073,4242353)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (36617886,254591,4248073,4242353))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 2) ) C

– End Condition Occurrence Criteria

– End Primary Events ) pe

) QE

;

— Inclusion Rule Inserts

select 0 as inclusion_rule_id, person_id, event_id INTO #Inclusion_0 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 2) ) C

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= DATEADD(day,1,P.START_DATE) AND A.START_DATE <= DATEADD(day,60,P.START_DATE) ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

SELECT inclusion_rule_id, person_id, event_id INTO #inclusion_events FROM (select inclusion_rule_id, person_id, event_id from #Inclusion_0) I; TRUNCATE TABLE #Inclusion_0; DROP TABLE #Inclusion_0;

– the matching group with all bits set ( POWER(2,# of inclusion rules) - 1 = inclusion_rule_mask WHERE (MG.inclusion_rule_mask = POWER(cast(2 as bigint),1)-1)

) Results WHERE Results.ordinal = 1 ;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

All events of Hospitalization for Serious Infection plus COVID, bronchitis, influenza and CMV

Cohort Entry Events

People may enter the cohort when observing any of the following:

visit occurrences of ‘Inpatient visits’.

Inclusion Criteria

1. Diagnosis of a serious infection (i.e., bacteremia, pneumonia, skin/soft tissue infection, gastrointestinal infection, acute osteomyelitis, acute pyelonephritis, acute meningitis)

Entry events with any of the following criteria:

having at least 1 condition occurrence of ‘Acute Meningitis’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Acute osteomyelitis’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Bacteremia’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Pneumonia’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Pyelonephritis’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Serious GI Infection’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Skin and Soft Tissue infections’, starting between 0 days before and all days after cohort entry start date and starting anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘COVID-19’, starting between 0 days before and all days after cohort entry start date and ending anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 observation of ‘COVID-19’, starting between 0 days before and all days after cohort entry start date and ending anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Bronchitis’, starting between 0 days before and all days after cohort entry start date and ending anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Influenza’, starting between 0 days before and all days after cohort entry start date and ending anytime on or before cohort entry end date; allow events outside observation period.
having at least 1 condition occurrence of ‘Cytomegalovirus’, starting between 0 days before and all days after cohort entry start date and ending anytime on or before cohort entry end date; allow events outside observation period.

2. an infections (RX or DX) within 7 days prior index : Either of the following recorded within 7 days prior to or on the date of hospital admission for serious infection: (a) outpatient or emergency department ICD-10-CM diagnosis (in any position) of any serious or non-serious infection (Appendix Table S2),

Entry events with any of the following criteria:

having at least 1 drug exposure of ‘Any antimicrobial by ATC’, starting between 7 days before and 0 days before cohort entry start date; allow events outside observation period; with all of the following criteria:
1. having no visit occurrences of ‘Inpatient visits’, starting between 0 days before and 0 days after ‘Any antimicrobial by ATC’ start date.
2. having no procedure occurrences of ‘Inpatient visits’, starting between 0 days before and 0 days after ‘Any antimicrobial by ATC’ start date.
3. having no observations of ‘Inpatient visits’, starting between 0 days before and 0 days after ‘Any antimicrobial by ATC’ start date.
having at least 1 condition occurrence of ‘Any serious or non-serious infection by Lo Re’, starting between 7 days before and 0 days before cohort entry start date; allow events outside observation period; having at least 1 visit occurrence of ‘Outpatient or ER visit’, starting between 0 days before and 0 days before ‘Any serious or non-serious infection by Lo Re’ start date.

Cohort Exit

The cohort end date will be offset from index event’s end date plus 0 days.

Cohort Eras

Remaining events will be combined into cohort eras if they are within 1 days of each other.

{ “cdmVersionRange” : “>=5.0.0”, “PrimaryCriteria” : { “CriteriaList” : [ { “VisitOccurrence” : { “CodesetId” : 0, “VisitTypeExclude” : false } } ], “ObservationWindow” : { “PriorDays” : 0, “PostDays” : 0 }, “PrimaryCriteriaLimit” : { “Type” : “All” } }, “ConceptSets” : [ { “id” : 0, “name” : “Inpatient visits”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 9201, “CONCEPT_NAME” : “Inpatient Visit”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “IP”, “DOMAIN_ID” : “Visit”, “VOCABULARY_ID” : “Visit”, “CONCEPT_CLASS_ID” : “Visit” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 262, “CONCEPT_NAME” : “Emergency Room and Inpatient Visit”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “ERIP”, “DOMAIN_ID” : “Visit”, “VOCABULARY_ID” : “Visit”, “CONCEPT_CLASS_ID” : “Visit” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } }, { “id” : 2, “name” : “Acute Meningitis”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 434869, “CONCEPT_NAME” : “Aseptic leptospiral meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “25957002”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 437772, “CONCEPT_NAME” : “Salmonella meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “77645007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4088214, “CONCEPT_NAME” : “Plague meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “186284005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4105195, “CONCEPT_NAME” : “Actinomycotic meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “192649000”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 441775, “CONCEPT_NAME” : “Tuberculosis of meninges”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “58437007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4044930, “CONCEPT_NAME” : “Meningitis in Lyme disease”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “230150008”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4136344, “CONCEPT_NAME” : “Listeria meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “31568009”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 438338, “CONCEPT_NAME” : “Meningococcal meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “192644005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 436903, “CONCEPT_NAME” : “Adenoviral meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “111850006”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 434860, “CONCEPT_NAME” : “Lymphocytic choriomeningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “398136003”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4102297, “CONCEPT_NAME” : “Enterovirus meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “28192008”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 433403, “CONCEPT_NAME” : “Viral meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “58170007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 441787, “CONCEPT_NAME” : “Herpes simplex meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “23291008”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 440323, “CONCEPT_NAME” : “Herpes zoster with meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “10491005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4088376, “CONCEPT_NAME” : “Measles complicated by meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “186561002”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 45757267, “CONCEPT_NAME” : “Meningitis caused by Rubella virus”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “1092351000119107”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 442336, “CONCEPT_NAME” : “Mumps meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “44201003”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 46269917, “CONCEPT_NAME” : “Meningitis due to infectious mononucleosis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “1089791000119107”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 46269857, “CONCEPT_NAME” : “Meningitis due to Cytomegaloviral Mononucleosis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “1085361000119104”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 432556, “CONCEPT_NAME” : “Candidal meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “45021001”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 435182, “CONCEPT_NAME” : “Coccidioidal meningitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “46303000”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4089362, “CONCEPT_NAME” : “Cerebral 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“Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4110485, “CONCEPT_NAME” : “Acute echovirus bronchitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “195729007”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4309350, “CONCEPT_NAME” : “Fetid chronic bronchitis”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “84409004”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : false, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4208810, “CONCEPT_NAME” : “Acute infective 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“INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “6142004”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4112824, “CONCEPT_NAME” : “Influenza with gastrointestinal tract involvement”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “195929004”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4146943, “CONCEPT_NAME” : “Encephalitis due to influenza”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “309789002”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 4299935, “CONCEPT_NAME” : “Myocarditis due to influenza virus”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “78046005”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false }, { “concept” : { “CONCEPT_ID” : 46269706, “CONCEPT_NAME” : “Otitis media due to influenza”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “10624951000119108”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } }, { “id” : 17, “name” : “Cytomegalovirus”, “expression” : { “items” : [ { “concept” : { “CONCEPT_ID” : 440032, “CONCEPT_NAME” : “Cytomegalovirus infection”, “STANDARD_CONCEPT” : “S”, “STANDARD_CONCEPT_CAPTION” : “Standard”, “INVALID_REASON” : “V”, “INVALID_REASON_CAPTION” : “Valid”, “CONCEPT_CODE” : “28944009”, “DOMAIN_ID” : “Condition”, “VOCABULARY_ID” : “SNOMED”, “CONCEPT_CLASS_ID” : “Disorder” }, “isExcluded” : false, “includeDescendants” : true, “includeMapped” : false } ] } } ], “QualifiedLimit” : { “Type” : “First” }, “ExpressionLimit” : { “Type” : “All” }, “InclusionRules” : [ { “name” : “Diagnosis of a serious infection (i.e., bacteremia, pneumonia, skin/soft tissue infection, gastrointestinal infection, acute osteomyelitis, acute pyelonephritis, acute meningitis)”, “expression” : { “Type” : “ANY”, “CriteriaList” : [ { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 2 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 3 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 4 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 5 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 6 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 7 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 12 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : true, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 14 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : true, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “Observation” : { “CodesetId” : 14, “ObservationTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : true, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 15 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : true, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 16 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : true, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CodesetId” : 17 } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “EndWindow” : { “Start” : { “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : true, “UseEventEnd” : true }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } }, { “name” : ” an infections (RX or DX) within 7 days prior index “,”description” : “Either of the following recorded within 7 days prior to or on the date of hospital admission for serious infection: (a) outpatient or emergency department ICD-10-CM diagnosis (in any position) of any serious or non-serious infection (Appendix Table S2),”, “expression” : { “Type” : “ANY”, “CriteriaList” : [ { “Criteria” : { “DrugExposure” : { “CorrelatedCriteria” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “VisitOccurrence” : { “CodesetId” : 0, “VisitTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “ProcedureOccurrence” : { “CodesetId” : 0, “ProcedureTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } }, { “Criteria” : { “Observation” : { “CodesetId” : 0, “ObservationTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : 1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 0, “Count” : 0, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] }, “CodesetId” : 13, “DrugTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 7, “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } }, { “Criteria” : { “ConditionOccurrence” : { “CorrelatedCriteria” : { “Type” : “ALL”, “CriteriaList” : [ { “Criteria” : { “VisitOccurrence” : { “CodesetId” : 10, “VisitTypeExclude” : false } }, “StartWindow” : { “Start” : { “Days” : 0, “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : false, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] }, “CodesetId” : 11 } }, “StartWindow” : { “Start” : { “Days” : 7, “Coeff” : -1 }, “End” : { “Days” : 0, “Coeff” : -1 }, “UseIndexEnd” : false, “UseEventEnd” : false }, “RestrictVisit” : false, “IgnoreObservationPeriod” : true, “Occurrence” : { “Type” : 2, “Count” : 1, “IsDistinct” : false } } ], “DemographicCriteriaList” : [], “Groups” : [] } } ], “EndStrategy” : { “DateOffset” : { “DateField” : “EndDate”, “Offset” : 0 } }, “CensoringCriteria” : [], “CollapseSettings” : { “CollapseType” : “ERA”, “EraPad” : 1 }, “CensorWindow” : {} }

CREATE TABLE #Codesets ( codeset_id int NOT NULL, concept_id bigint NOT NULL ) ;

INSERT INTO #Codesets (codeset_id, concept_id) SELECT 0 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (9201,262)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (9201,262))

) I ) C UNION ALL SELECT 2 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (434869,437772,4088214,4105195,441775,4044930,4136344,438338,436903,434860,4102297,433403,441787,440323,4088376,45757267,442336,46269917,46269857,432556,435182,4089362,46269916,437538,440390,436090,432879,436091,4044931,435785)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (434869,437772,4088214,441775,4044930))

) I ) C UNION ALL SELECT 3 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (133002,4284844,134137,133003,133296,138847,137648,443631,140191,133853,141663)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (133002))

) I ) C UNION ALL SELECT 4 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (40486631,132736,40493038,4091311,46269946,437777,132797,40486685)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (40486631,132736,40493038,4091311,40486685))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (442137,4345708,133594,4310674,4071727,42538750,442019)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4345708,133594,4310674,4071727,42538750,442019))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 5 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (253506,256622,4049797,4097550,4087776,443741,4241693,4087778,438350)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (253506,4049797,4097550,4087776,4241693))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (253954,436632,45757250,4345232,257583,4080753,4051334,4086243,36676238,605209,4310964,260125,4222731,252946,256450,4119446,259044,4306082,4221139,444084,3655110,253506,45763749,260434,4279553,46274046,259992,255084)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (253954,45757250,4345232,257583,4080753,4051334,4086243,260125,4222731,252946,256450,4119446,259044,4306082,4221139,444084,3655110,45763749,260434,4279553,46274046,259992,255084))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 6 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4280571,35209268)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4280571))

) I ) C UNION ALL SELECT 7 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (193402,198076,4220074,196149,44784251,440448,35208257,4136809,46269903,4154614,45591596,45552938,4057822,45567317,45605946,45586726,45576994,45557662,45552940,197328,193240,200757,199863,200440,196152,200761,201901,198809,4288676,35208372,199074,4049458)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (46269903,4154614,199863,200440,199074))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4009168,196469,4340493)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4009168,4340493))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 10 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (9202,8756,9203)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (9202,8756,9203))

) I ) C UNION ALL SELECT 11 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4294300,4273095,4310400,433524,40481852,4341763,4340964,256451,45769350,45768908,26711,257004,4148121,261599,42537252,4112826,46270529,199074,437904,195596,439743,31602,4234127,196029,132932,434854,438788,134668,28457,4340960,255573,139841,4134562,261325,254387,313236,4266809,260123,4034633,602297,255566,45768910,439928,257012,37116845,437663,23798,256439,4295722,40481374,141323,4138403,4136809,435785,4057524,254068,4177944,4033662,317009,46270516,4146581,35615028,45772937,44806251,439851,4286497,36712963,255841,196152,440129,141056,440448,23220,259848,4177206,24970,436641,31057,435468,36714927,261889,200765,192239,4110362,381504,24660,36685933,45769438,4048489,4044931,25297,432250,45769351,132797,260125,4049458,4305500,24974,42537251,4227902,435840,4280726,139850,4060950,4324261,260130,45769352,257583,31597,46269900,260139,434866,377802,4340493,4270705,4271511,432347,4165681,40483342,4138760,22350,257581,28179,437496,132736,45768911,4288676,46269907,318222,4260535,26719,45757557,36717279,36685932,254669,137900,4309525,443558,79072,4134144,4048485,193240,46271527,257007,4173734,315558,256449,45768963,441321,439407,444202,4230641,604358,435613,193239,4340961,134661,192956,45768964,4151978,4051447,198809,255848,377910,4260546,200440,433513,37312531,4163133,45768965,441406,30133,46273522,440140)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (196029,434854,437663,4057524,432250,132797,132736,318222,444202,435613,4051447,255848))

) I LEFT JOIN ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (45763750,3654996)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (45763750,3654996))

) E ON I.concept_id = E.concept_id WHERE E.concept_id is null ) C UNION ALL SELECT 12 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (141498,436021,4276193,138346,433696,381308,434942,765316,760152,4334404,4339469,37312531,46273522,439928,4048485,4324261,136496,45772085,4262720,443327,4326601,140480,4061734,132391,444418,4266864,436188,200171,4214610,4078384,4228164,4195436,4147598,4137468,4266590,4273250,4029776,4154088,4151763,4061735,4220002,4200967,4248277,4212079,435613,4165681,444202,4033662,443600,133566,4212378,4153106,4060950,35209371)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (381308,434942,765316,760152,4334404,4339469,37312531,46273522,140480,444418,4266864,200171,4214610,4078384,4228164,4195436,4029776,4220002,435613))

) I ) C UNION ALL SELECT 13 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (1736971,1703687,1729323,19123877,19088223,1790868,19010337,1726228,1713332,1717240,1717327,1789428,19026450,19101402,46233931,1727223,46221507,19018516,1734104,19015123,1715117,1734205,915175,43012398,35201105,43012518,40238770,19122130,19018742,739588,19026710,1740546,1718054,1768849,1769535,19070174,19070680,1771162,1796458,1747005,1748975,19028241,37498010,1796435,19072255,19028286,19072857,1773402,19028288,1774470,1774932,19051271,1775741,19001904,1749008,1738366,19051345,46274210,1776684,1749083,1777254,45892599,1777806,1778162,1786621,19052683,19086759,19086790,1786842,990069,19095043,1745072,997496,1797513,1750500,1759842,997881,1798476,19047240,19047265,1800835,901845,1710446,46221696,45774861,1711759,1786617,1756831,45892558,1592954,1747157,1714527,19023508,1724666,1724869,1790024,43560385,35200446,1713905,1738521,1738135,35606465,42874212,1703069,1717002,1743222,1711246,35200469,1717963,1746940,1749301,1750074,1758536,1703603,19050750,19054936,1754994,1755112,19064329,1736829,1724700,956653,1146410,19010400,1757803,1789276,1716721,45892419,793843,35606467,1747032,19069006,42544019,19078156,1778262,1711523,19083285,35606695,1782521,1703653,19123240,1784749,985708,1704183,37496518,792929,1742253,1790692,1736887,1707800,1738170,1708100,19092353,43532424,19008870,1787101,1709170,19003644,19072054,904356,1361385,1707164,19007701,19018013,907879,19072122,1708880,19009138,19010924,19126622,1716903,1713930,986864,1715472,915981,19017585,1769389,920293,19015464,1721543,923081,19023254,35200953,45892552,45776147,19024197,1799139,1724703,19129642,925952,19027679,981654,1728416,1729720,40167569,19088795,19010564,1746114,19047071,1560047,948582,1704139,37496482,19125201,19096054,19135812,1759455,1789515,1712889,37499271,1762711,1777417,1763204,19136008,19035924,19035953,40238930,1763339,1748921,19136024,19036545,19063874,1746244,35200881,44785086,19136044,44785094,1733765,1701651,19070251,1781406,1836191,19136210,1836241,19000817,1836391,19000818,19136423,19136426,19136429,1036425,1836430,19000820,19040624,19136481,1036475,19136493,1036487,19000821,1836503,19002077,1741122,35200354,45775686,19078399,40239330,40166675,1758392,1702911,19041153,19100438,35605546,1710281,19078424,1836948,19137362,1702364,1742432,1702559,1736999,902722,1705674,19006043,19101679,1712549,792531,1717704,1703063,1707687,908126,1714277,19102105,1724827,1708748,1710612)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (1736971,1703687,1729323,19123877,19088223,1790868,19010337,1726228,1713332,1717240,1717327,1789428,19026450,19101402,46233931,1727223,46221507,19018516,1734104,19015123,1715117,1734205,915175,43012398,35201105,43012518,40238770,19122130,19018742,739588,19026710,1740546,1718054,1768849,1769535,19070174,19070680,1771162,1796458,1747005,1748975,19028241,37498010,1796435,19072255,19028286,19072857,1773402,19028288,1774470,1774932,19051271,1775741,19001904,1749008,1738366,19051345,46274210,1776684,1749083,1777254,45892599,1777806,1778162,1786621,19052683,19086759,19086790,1786842,990069,19095043,1745072,997496,1797513,1750500,1759842,997881,1798476,19047240,19047265,1800835,901845,1710446,46221696,45774861,1711759,1786617,1756831,45892558,1592954,1747157,1714527,19023508,1724666,1724869,1790024,43560385,35200446,1713905,1738521,1738135,35606465,42874212,1703069,1717002,1743222,1711246,35200469,1717963,1746940,1749301,1750074,1758536,1703603,19050750,19054936,1754994,1755112,19064329,1736829,1724700,956653,1146410,19010400,1757803,1789276,1716721,45892419,793843,35606467,1747032,19069006,42544019,19078156,1778262,1711523,19083285,35606695,1782521,1703653,19123240,1784749,985708,1704183,37496518,792929,1742253,1790692,1736887,1707800,1738170,1708100,19092353,43532424,19008870,1787101,1709170,19003644,19072054,904356,1361385,1707164,19007701,19018013,907879,19072122,1708880,19009138,19010924,19126622,1716903,1713930,986864,1715472,915981,19017585,1769389,920293,19015464,1721543,923081,19023254,35200953,45892552,45776147,19024197,1799139,1724703,19129642,925952,19027679,981654,1728416,1729720,40167569,19088795,19010564,1746114,19047071,1560047,948582,1704139,37496482,19125201,19096054,19135812,1759455,1789515,1712889,37499271,1762711,1777417,1763204,19136008,19035924,19035953,40238930,1763339,1748921,19136024,19036545,19063874,1746244,35200881,44785086,19136044,44785094,1733765,1701651,19070251,1781406,1836191,19136210,1836241,19000817,1836391,19000818,19136423,19136426,19136429,1036425,1836430,19000820,19040624,19136481,1036475,19136493,1036487,19000821,1836503,19002077,1741122,35200354,45775686,19078399,40239330,40166675,1758392,1702911,19041153,19100438,35605546,1710281,19078424,1836948,19137362,1702364,1742432,1702559,1736999,902722,1705674,19006043,19101679,1712549,792531,1717704,1703063,1707687,908126,1714277,19102105,1724827,1708748,1710612))

) I ) C UNION ALL SELECT 14 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (37311061,704996,704995,704999,704997)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (37311061,704996,704995,704999,704997))

) I ) C UNION ALL SELECT 15 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4112826,4110481,4112355,257905,4233477,4243199,37206139,46273460,4112358,4233784,4110023,4270139,4112015,4148242,4208807,4233924,4052543,4049964,4112359,4232302,37203939,37206130,4112357,4105601,3655116,4230358,255841,4058712,4112521,258780,4110483,4148204,261889,4110484,37206138,256451,4028970,4051332,4099911,4137525,765431,4200851,42536541,4197404,4195736,4110485,4309350,4208810,260139))

) I ) C UNION ALL SELECT 16 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (4266367,4112824,4146943,4299935,46269706)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (4266367,4112824,4146943,4299935,46269706))

) I ) C UNION ALL SELECT 17 as codeset_id, c.concept_id FROM (select distinct I.concept_id FROM ( select concept_id from @vocabulary_database_schema.CONCEPT where (concept_id in (440032)) UNION select c.concept_id from @vocabulary_database_schema.CONCEPT c join @vocabulary_database_schema.CONCEPT_ANCESTOR ca on c.concept_id = ca.descendant_concept_id WHERE c.invalid_reason is null and (ca.ancestor_concept_id in (440032))

) I ) C;

UPDATE STATISTICS #Codesets;

SELECT event_id, person_id, start_date, end_date, op_start_date, op_end_date, visit_occurrence_id INTO #qualified_events FROM ( select pe.event_id, pe.person_id, pe.start_date, pe.end_date, pe.op_start_date, pe.op_end_date, row_number() over (partition by pe.person_id order by pe.start_date ASC) as ordinal, cast(pe.visit_occurrence_id as bigint) as visit_occurrence_id FROM (– Begin Primary Events select P.ordinal as event_id, P.person_id, P.start_date, P.end_date, op_start_date, op_end_date, cast(P.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( select E.person_id, E.start_date, E.end_date, row_number() OVER (PARTITION BY E.person_id ORDER BY E.sort_date ASC, E.event_id) ordinal, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date, cast(E.visit_occurrence_id as bigint) as visit_occurrence_id FROM ( – Begin Visit Occurrence Criteria select C.person_id, C.visit_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date from ( select vo.person_id,vo.visit_occurrence_id,vo.visit_concept_id,vo.visit_start_date as start_date, vo.visit_end_date as end_date FROM @cdm_database_schema.VISIT_OCCURRENCE vo JOIN #Codesets cs on (vo.visit_concept_id = cs.concept_id and cs.codeset_id = 0) ) C

– End Visit Occurrence Criteria

– End Primary Events ) pe

) QE

;

— Inclusion Rule Inserts

select 0 as inclusion_rule_id, person_id, event_id INTO #Inclusion_0 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 2) ) C

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= DATEADD(day,0,P.START_DATE) AND A.START_DATE <= DATEADD(day,0,P.END_DATE) ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 3) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 4) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 3 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 5) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 4 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 6) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 5 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 7) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 6 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 12) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 7 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

– End Condition Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= DATEADD(day,0,P.START_DATE) AND A.END_DATE <= DATEADD(day,0,P.END_DATE) ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 8 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Observation Criteria select C.person_id, C.observation_id as event_id, C.start_date, C.END_DATE, C.visit_occurrence_id, C.start_date as sort_date from ( select o.person_id,o.observation_id,o.observation_concept_id,o.visit_occurrence_id,o.value_as_number,o.observation_date as start_date, DATEADD(day,1,o.observation_date) as end_date FROM @cdm_database_schema.OBSERVATION o JOIN #Codesets cs on (o.observation_concept_id = cs.concept_id and cs.codeset_id = 14) ) C

– End Observation Criteria

UNION ALL – Begin Correlated Criteria select 9 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 15) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 10 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 16) ) C

– End Condition Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 11 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 17) ) C

– End Condition Occurrence Criteria

select 1 as inclusion_rule_id, person_id, event_id INTO #Inclusion_1 FROM ( select pe.person_id, pe.event_id FROM #qualified_events pe

JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM #qualified_events E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( select PE.person_id, PE.event_id, PE.start_date, PE.end_date, PE.visit_occurrence_id, PE.sort_date FROM ( – Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Drug Exposure Criteria

) PE JOIN ( – Begin Criteria Group select 0 as index_id, person_id, event_id FROM ( select E.person_id, E.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Drug Exposure Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Drug Exposure Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Visit Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Drug Exposure Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Procedure Occurrence Criteria

UNION ALL – Begin Correlated Criteria select 2 as index_id, p.person_id, p.event_id from (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Drug Exposure Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) p LEFT JOIN ( SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Drug Exposure Criteria select C.person_id, C.drug_exposure_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id,C.start_date as sort_date from ( select de.person_id,de.drug_exposure_id,de.drug_concept_id,de.visit_occurrence_id,days_supply,quantity,refills,de.drug_exposure_start_date as start_date, COALESCE(de.drug_exposure_end_date, DATEADD(day,de.days_supply,de.drug_exposure_start_date), DATEADD(day,1,de.drug_exposure_start_date)) as end_date FROM @cdm_database_schema.DRUG_EXPOSURE de JOIN #Codesets cs on (de.drug_concept_id = cs.concept_id and cs.codeset_id = 13) ) C

– End Observation Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= DATEADD(day,-7,P.START_DATE) AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

UNION ALL – Begin Correlated Criteria select 1 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM #qualified_events P JOIN ( select PE.person_id, PE.event_id, PE.start_date, PE.end_date, PE.visit_occurrence_id, PE.sort_date FROM ( – Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 11) ) C

– End Condition Occurrence Criteria

– End Condition Occurrence Criteria ) Q JOIN @cdm_database_schema.OBSERVATION_PERIOD OP on Q.person_id = OP.person_id and OP.observation_period_start_date <= Q.start_date and OP.observation_period_end_date >= Q.start_date ) E INNER JOIN ( – Begin Correlated Criteria select 0 as index_id, cc.person_id, cc.event_id from (SELECT p.person_id, p.event_id FROM (SELECT Q.person_id, Q.event_id, Q.start_date, Q.end_date, Q.visit_occurrence_id, OP.observation_period_start_date as op_start_date, OP.observation_period_end_date as op_end_date FROM (– Begin Condition Occurrence Criteria SELECT C.person_id, C.condition_occurrence_id as event_id, C.start_date, C.end_date, C.visit_occurrence_id, C.start_date as sort_date FROM ( SELECT co.person_id,co.condition_occurrence_id,co.condition_concept_id,co.visit_occurrence_id,co.condition_start_date as start_date, COALESCE(co.condition_end_date, DATEADD(day,1,co.condition_start_date)) as end_date FROM @cdm_database_schema.CONDITION_OCCURRENCE co JOIN #Codesets cs on (co.condition_concept_id = cs.concept_id and cs.codeset_id = 11) ) C

– End Visit Occurrence Criteria

) A on A.person_id = P.person_id AND A.START_DATE >= P.OP_START_DATE AND A.START_DATE <= P.OP_END_DATE AND A.START_DATE >= DATEADD(day,0,P.START_DATE) AND A.START_DATE <= DATEADD(day,0,P.START_DATE) ) cc GROUP BY cc.person_id, cc.event_id HAVING COUNT(cc.event_id) >= 1 – End Correlated Criteria

TRUNCATE TABLE #Inclusion_1; DROP TABLE #Inclusion_1;

– the matching group with all bits set ( POWER(2,# of inclusion rules) - 1 = inclusion_rule_mask WHERE (MG.inclusion_rule_mask = POWER(cast(2 as bigint),2)-1)

) Results

;

– date offset strategy

select event_id, person_id, case when DATEADD(day,0,end_date) > op_end_date then op_end_date else DATEADD(day,0,end_date) end as end_date INTO #strategy_ends from #included_events;

– generate cohort periods into #final_cohort select person_id, start_date, end_date INTO #cohort_rows from ( – first_ends select F.person_id, F.start_date, F.end_date FROM ( select I.event_id, I.person_id, I.start_date, CE.end_date, row_number() over (partition by I.person_id, I.event_id order by CE.end_date) as ordinal from #included_events I join ( – cohort_ends – cohort exit dates – End Date Strategy SELECT event_id, person_id, end_date from #strategy_ends

) CE on I.event_id = CE.event_id and I.person_id = CE.person_id and CE.end_date >= I.start_date
) F
WHERE F.ordinal = 1

) FE;

select person_id, min(start_date) as start_date, DATEADD(day,-1 * 1, max(end_date)) as end_date into #final_cohort from ( select person_id, start_date, end_date, sum(is_start) over (partition by person_id order by start_date, is_start desc rows unbounded preceding) group_idx from ( select person_id, start_date, end_date, case when max(end_date) over (partition by person_id order by start_date rows between unbounded preceding and 1 preceding) >= start_date then 0 else 1 end is_start from ( select person_id, start_date, DATEADD(day,1,end_date) as end_date from #cohort_rows ) CR ) ST ) GR group by person_id, group_idx;

TRUNCATE TABLE #strategy_ends; DROP TABLE #strategy_ends;

TRUNCATE TABLE #cohort_rows; DROP TABLE #cohort_rows;

TRUNCATE TABLE #final_cohort; DROP TABLE #final_cohort;

TRUNCATE TABLE #inclusion_events; DROP TABLE #inclusion_events;

TRUNCATE TABLE #qualified_events; DROP TABLE #qualified_events;

TRUNCATE TABLE #included_events; DROP TABLE #included_events;

TRUNCATE TABLE #Codesets; DROP TABLE #Codesets;

Plans for disseminating and communicating study results

The final results will be disseminated as a journal article.

All statistical analysis code will be made publicly available. This includes the study package for the network study and a cohort diagnostic package.